New lung cancer pill takes on chemo in major trial

NCT ID NCT06881784

Recruiting now Disease control Sponsor: Revolution Medicines, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 6 times

Summary

This Phase 3 trial is testing a new oral drug called daraxonrasib (RMC-6236) against the standard chemotherapy docetaxel in about 590 people with advanced non-small cell lung cancer that has a specific RAS mutation. Participants must have already tried at least one prior treatment including immunotherapy and platinum chemo. The study aims to see if the new drug can delay cancer growth and improve survival better than chemo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: daraxonrasib (RMC-6236)
What this could lead to: If it works, this could offer a new targeted treatment option for people with a specific type of advanced lung cancer that has stopped responding to standard therapies.
What could go wrong: This is an early-stage Phase 3 trial, so results are not yet known. The new drug may not prove more effective than docetaxel and could have unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

lung neoplasm non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER NSCLC NSCLC (ADVANCED NON-SMALL CELL LUNG CANCER) NSCLC (NON-SMALL CELL LUNG CANCER) NSCLC (NON-SMALL CELL LUNG CARCINOMA)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

AZ Delta
RECRUITING

Roeselare, 8800, Belgium
AZ Groeninge
RECRUITING

Kortrijk, 8500, Belgium
Aichi Cancer Center Hospital
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Aidport Sp. z o.o.
RECRUITING

Skorzewo, 60-185, Poland
Ajou University Hospital
RECRUITING

Gyeonggi-do, Suwon-si, 16499, South Korea
Alabama Oncology
RECRUITING

Birmingham, Alabama, 35243, United States
Alfred House
RECRUITING

Melbourne, Victoria, 3004, Australia
Amsterdam UMC, Locatie VUMC
RECRUITING

Amsterdam, Netherlands, 1081BT, Netherlands
Antoni van Leeuwenhoek
RECRUITING

Amsterdam, 1066 CX, Netherlands
Auckland City Hospital - Cancer and Blood Research
RECRUITING

Grafton, Auckland, 1023, New Zealand
Avera Cancer Institute
RECRUITING

Sioux Falls, South Dakota, 57105, United States

Contact Email: •••••@•••••
Avera Saint Luke's Hospital
RECRUITING

Aberdeen, South Dakota, 57401, United States

Contact Email: •••••@•••••
Azienda Ospedaliero Universitaria Pisana (Presidio di Cisanello)
RECRUITING

Pisa, Pisa, 56124, Italy
Azienda Socio Sanitaria Territoriale Niguarda
RECRUITING

Milan, Milano, 21206, Italy
BRCR Global
RECRUITING

Plantation, Florida, 33322, United States
Beaumont Hospital Cancer Clinical
RECRUITING

Dublin, D09 V2N0, Ireland
Blacktown Medical Oncology Research
RECRUITING

Blacktown, New South Wales, 2148, Australia
Blacktown Medical Oncology Research, Blacktown Hospital
RECRUITING

Blacktown, New South Wales, 2148, Australia
CHU Brest - Hôpital Morvan
RECRUITING

Brest, 29200, France
CHU Nantes - Hôpital Guillaume et René Laënnec
RECRUITING

Saint-Herblain, Loire Atlantique, 44805, France
CHU Rennes Hôpital Pontchaillou
RECRUITING

Rennes, Ille et Vilaine, 35033, France
CHU Strasbourg - Nouvel Hôpital Civil
RECRUITING

Strasbourg, Bas Rhin, 67091, France
CHU de Grenoble - Hôpital Albert Michallon
RECRUITING

La Tronche, Isere, 38700, France
CHU de Toulouse - Hopital Larrey
RECRUITING

Toulouse, 31059, France
Calvary Mater Newcastle
RECRUITING

Waratah, New South Wales, 2298, Australia
Cancer Care Centers of Breevard
RECRUITING

Rockledge, Florida, 32955, United States
Cancer Institute Hospital of JFCR
RECRUITING

Koto-Ku, Tokyo, 135-8550, Japan
Center for Care and Discovery
RECRUITING

Chicago, Illinois, 60637, United States

Contact Email: •••••@•••••
Centre Hospitalier Intercommunal de Créteil
RECRUITING

Créteil, Val de Marne, 94000, France
Centre Leon Berard
RECRUITING

Léon, Lyon, 69008, France
Chang Gung Medical Foundation Linkou
RECRUITING

Taoyuan, 333, Taiwan
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun, 58128, South Korea
Chris O'Brien Lifehouse
RECRUITING

Camperdown, New South Wales, 2050, Australia
Chungbuk National University Hospital
RECRUITING

Cheongju-si, 28644, South Korea
Cleveland Clinic Martin North
RECRUITING

Stuart, Florida, 34994, United States
Complejo Hospitalario Universitario A Coruña
RECRUITING

A Coruña, A Coruña, 15006, Spain
Cork Univeristy Hospital
RECRUITING

Cork, Cork, T12 DC4A, Ireland
Dartmouth-Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Erasmus Medisch Centrum
RECRUITING

Rotterdam, Netherlands, 3015AA, Netherlands
Evangelische Lungenklinik Berlin
RECRUITING

Berlin, 13125, Germany
Florida Cancer Specialists & Research Institute - East
RECRUITING

West Palm Beach, Florida, 33401, United States

Contact Email: •••••@•••••
Florida Cancer Specialists & Research Institute - North
RECRUITING

St. Petersburg, Florida, 33705, United States

Contact Email: •••••@•••••
Florida Cancer Specialists & Research Institute - South
RECRUITING

Fort Myers, Florida, 33901, United States

Contact Email: •••••@•••••
Fondazione IRCCS San Gerardo dei Tintori
RECRUITING

Monza, Milan, 20900, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Rome, 00168, Italy
Fujita Health University Hospital
RECRUITING

Toyoake-shi, Aichi-ken, 470-1192, Japan
Galway University Hospital
RECRUITING

Galway, H91 YR71, Ireland
Grand Hôpital de Charleroi - Les Viviers
RECRUITING

Gilly, 6060, Belgium
HFR Fribourg/Kantonsspital Fribourg
RECRUITING

Fribourg, 1708, Switzerland
Henry Ford Health
RECRUITING

Detroit, Michigan, 48202, United States
Hong Kong United Oncology Centre
RECRUITING

Hong Kong, Hong Kong

Contact Email: •••••@•••••
Hopital Albert Calmette - CHU Lille
RECRUITING

Lille, Nord, 59037, France
Hopital Louis Pradel
RECRUITING

Bron, Rhone, 69677, France
Hopital Nord - CHU Marseille
RECRUITING

Marseille, Bouches-du-Rhône, 13915, France
Hospital Universitari Dexeus
RECRUITING

Barcelona, Barcelona, 08028, Spain
Hospital Universitario HM Madrid Sanchinarro
RECRUITING

Madrid, Madrid, 28050, Spain
Hospital Universitario La Paz
RECRUITING

Fuencarral-El Pardo, Madrid, 28046, Spain
Hospital de la Santa Creu i Sant Pau
RECRUITING

Barcelona, 08041, Spain
Huntsman Cancer Institute
RECRUITING

Salt Lake City, Utah, 84112, United States
Hyogo Cancer Center
RECRUITING

Akashi, Hyōgo, 673-8558, Japan
Hôpital Bichat - Claude Bernard
RECRUITING

Paris, Paris, 75018, France
IEO Istituto Europeo di Oncologia
RECRUITING

Milan, Milano, 20141, Italy
INSTYTUT GENETYKI I IMMMUNOLOGII GENIM sp. z o.o.
RECRUITING

Lublin, 29-609, Poland
Icon Cancer Centre
RECRUITING

Singapore, 574623, Singapore
Institut Bergonie
RECRUITING

Gironde, 33076, France
Institut Gustave Roussy
RECRUITING

Vaillant, Villejuif, 94800, France
Institut Jules Bordet
RECRUITING

Anderlecht, Belgium, 1070, Belgium
Institut de Cancerologie de l Ouest
RECRUITING

Saint-Herblain, Loire Atlantique, 44805, France
Institut régional du Cancer de Montpellier
RECRUITING

Montpellier, Herault, 34298, France
Istituto Clinico Humanitas
RECRUITING

Rossano, Milano, 20089, Italy
Istituto Nazionale Tumori Fondazione G. Pascale
RECRUITING

Naples, Napoli, 80131, Italy
Istituto Nazionale dei Tumori Regina Elena IRCCS
RECRUITING

Roma, Roma, 00144, Italy
John Theurer Cancer Center at Hackensack UMC
RECRUITING

Hackensack, New Jersey, 07601, United States
Johns Hopkins University of Medicine
RECRUITING

Baltimore, Maryland, 21224, United States

Contact Email: •••••@•••••
Kanagawa Cancer Center
RECRUITING

Yokohama, Kanagawa, 241-8515, Japan
Kanazawa University Hospital
RECRUITING

Kanazawa, Ishikawa-ken, 920-8641, Japan
Kansai Medical University Hospital
RECRUITING

Hirakata-shi, Osaka, 573-1191, Japan
Kantonsspital St. Gallen
RECRUITING

Sankt Gallen, 9000, Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital
RECRUITING

Kaohsiung, Taiwan, 100, Taiwan
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Kindai University Hospital
RECRUITING

Osakasayama-shi, Osaka, 589-8511, Japan
Klinika Onkologii I Radioterapii UCK
RECRUITING

Gdansk, 80-214, Poland
Klinikum Esslingen GmbH
RECRUITING

Baden, 73730, Germany
Korea University Anam Hospital
RECRUITING

Seoul, 02841, South Korea
LKI Lungenfachklinik Immenhausen
RECRUITING

Immenhausen, Hesse, 34376, Germany
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Maastricht University Medical Center P. Debyelaan 25
RECRUITING

Maastricht, 6229, Netherlands
Mater Misericordiae Limited
RECRUITING

South Brisbane, Queensland, 4101, Australia

Contact Email: •••••@•••••
Mater Private Hospital
RECRUITING

Dublin, Dublin, 7, Ireland
Med-Polonia Sp. z o.o.
RECRUITING

Poznan, 60-693, Poland
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
MemorialCare Long Beach Medical Center
RECRUITING

Long Beach, California, 90806, United States
Montefiore Medical Center
RECRUITING

The Bronx, New York, 10461, United States
Morristown Medical Center (MMCORC)
RECRUITING

Morristown, New Jersey, 07960, United States
NHO Himeji Medical Center
RECRUITING

Matsuyama, Ehime, 791-0280, Japan
NHO Shikoku Cancer Center
RECRUITING

Matsuyama, Ehime, 791-0280, Japan
Nara Medical University Hospital
RECRUITING

Kashihara-shi, Nara, 634-8522, Japan
National Cancer Center Hospital
RECRUITING

Chuo Ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East
RECRUITING

Kashiwa-shi, Chiba, 277-8577, Japan
National Cancer Centre Singapore
RECRUITING

Singapore, 168583, Singapore

Contact Email: •••••@•••••
National Cheng Kung University Hospital
RECRUITING

Tainan, Taiwan, 704, Taiwan
National Hospital Organization Hokkaido Cancer Center
RECRUITING

Sapporo, Hokkaido, 003-0804, Japan
National Taiwan University Hospital
RECRUITING

Taipei, Taiwan, 10002, Taiwan
National University Hospital
RECRUITING

Singapore, Singapore, 119074, Singapore
Niigata Cancer Center
RECRUITING

Niigata, Niigata, 951-8566, Japan
Oncology Associates of Oregon PC
RECRUITING

Eugene, Oregon, 97401, United States
Pan American Center for Oncology Trials
RECRUITING

San Juan, Puerto Rico, 00909, Puerto Rico

Contact Email: •••••@•••••
Penn State Milton S. Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033, United States
Piedmont Healthcare, Inc
RECRUITING

Atlanta, Georgia, 30318, United States
Queen Mary Hospital
RECRUITING

Hong Kong, Hong Kong

Contact Email: •••••@•••••
Radboudumc
RECRUITING

Nijmegen, 6525 GA, Netherlands

Contact Email: •••••@•••••
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Royal Free Hospital
RECRUITING

London, W3 2QG, United Kingdom
Royal Marsden Hospital-London
RECRUITING

London, Greater London, SW3 6JJ, United Kingdom
Royal Marsden Hospital-Sutton
RECRUITING

Sutton, Surrey, SM2 5PT, United Kingdom
SCRI Oncology Partners - Tennessee
RECRUITING

Nashville, Tennessee, 37203, United States
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Sendai Kousei Hospital
RECRUITING

Sendai, Miyagi, 981-0914, Japan
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Shizuoka Cancer Center
RECRUITING

Nagaizumi-chō, Shizuoka, 411-8777, Japan
Sir Charles Gairdner Hospital
RECRUITING

Perth, Western Australia, 6009, Australia
St. George Private Hospital Clinical Trials Unit
RECRUITING

Kogarah, New South Wales, 2217, Australia
St. Vincent Frontier Cancer Center
RECRUITING

Billings, Montana, 59102, United States
Taipei Medical University Hospital
RECRUITING

Taipei, 110, Taiwan
Tallaght University Hospital
RECRUITING

Dublin, 24, Ireland
Taylor Cancer Research Center
RECRUITING

Maumee, Ohio, 43537, United States
Texas Oncology - Gulf Coast
RECRUITING

The Woodlands, Texas, 77380, United States
Texas Oncology - South Austin
RECRUITING

Austin, Texas, 78745, United States
Texas Oncology Dallas
RECRUITING

Dallas, Texas, 75251, United States
The Chinese University of Hong Kong
RECRUITING

Shatin, 00000, Hong Kong
The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom
The Clatterbridge Cancer Centre
RECRUITING

Liverpool, Merseyside, L7 8YA, United Kingdom
The University of Kansas Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
Thoraxklinik Heidelberg gGmbH
RECRUITING

Baden, Wuerttemberg, 69469, Germany
Tohoku University Hospital
RECRUITING

Sendai, Miyagi, 980-8574, Japan
TriHealth Cancer & Blood Institute Research
RECRUITING

Cincinnati, Ohio, 45220, United States
UNC Lineberger Comprehensive Cancer Center at University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27599, United States
UZ Leuven-Campus Gasthuisberg
RECRUITING

Leuven, 3000, Belgium
Universitaetsklinikum Carl Gustav Carus TU Dresden
RECRUITING

Dresden, Saxony, 01307, Germany
Universitaetsklinikum Essen
RECRUITING

Essen, North Rhine-Westphalia, 45147, Germany
University Cancer and Blood Center
RECRUITING

Athens, Georgia, 30607, United States

Contact Email: •••••@•••••
University Hospital Limerick
RECRUITING

Cork, Limerick, V94 F858, Ireland
University of Iowa Health Care Cancer Services Quad Cities
RECRUITING

Bettendorf, Iowa, 52722, United States
University of Iowa Health Care, Mission Cancer + Blood
RECRUITING

Waukee, Iowa, 50263, United States
University of Iowa Hospitals & Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
Universitätsspital Basel
RECRUITING

Basel, 4031, Switzerland
Utah Cancer Specialists
RECRUITING

Salt Lake City, Utah, 84106, United States

Contact Email: •••••@•••••
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Wakayama Medical University Hospital
RECRUITING

Wakayama, Wakayama, 641-8510, Japan
Washington University School of Medicine - Siteman Cancer Center
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••
Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Yale University, Smillow Cancer Center
RECRUITING

New Haven, Connecticut, 06519, United States

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