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New drug cocktail shows promise for Tough-to-Treat T-Cell cancers

NCT ID NCT04447027

First seen Jan 31, 2026 · Last updated Jun 13, 2026 · Updated 18 times

Summary

This early-phase study tested a combination of four drugs (romidepsin, CC-486, dexamethasone, and lenalidomide) in 26 adults with T-cell cancers that had returned or stopped responding to standard treatments. The main goal was to find a safe dose and see how well patients tolerated the therapy. Researchers also looked for signs that the treatment was shrinking tumors.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

Conditions

The condition(s) this trial relates to.

mature T-cell and NK-cell non-Hodgkin lymphoma primary cutaneous T-cell non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.