Shrinking tumors before surgery: a new hope for breast cancer patients?
NCT ID NCT02186470
First seen Oct 31, 2025 · Last updated Jun 24, 2026 · Updated 37 times
Summary
This study tested whether giving a short, targeted course of radiation before surgery is feasible for older women with early-stage, hormone-positive breast cancer. The goal was to shrink the tumor and reduce the amount of breast tissue removed. Twenty-two participants received accelerated partial breast irradiation (APBI) followed by lumpectomy, and researchers measured how well the treatment plan worked and tracked side effects.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
accelerated partial breast irradiation (APBI) with intensity-modulated radiation therapy (IMRT)
What this could lead to
If successful, this approach could make breast cancer surgery less extensive by shrinking the tumor first, potentially improving cosmetic outcomes and reducing side effects.
What could go wrong
This is a small, early feasibility study with only 22 participants, so results may not apply to all patients. Radiation before surgery also carries risks like skin reactions or changes in breast appearance.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.