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Ancient herbal mix put to the test for chronic throat pain

NCT ID NCT05665777

Disease control Sponsor: Chinese University of Hong Kong Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This trial tests whether a Chinese herbal formula called Qingyan Lihou Decoction can relieve chronic pharyngolaryngitis — a long-lasting sore throat, dryness, and irritation. About 74 adults with persistent throat symptoms will receive either the herbal granules or a placebo for 8 weeks. Researchers will measure symptom improvement using throat exams and patient-reported scores.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a Chinese herbal formula called Qingyan Lihou Decoction
What this could lead to
If effective, this herbal formula could offer a new treatment option for people with chronic throat discomfort.
What could go wrong
This is a small, early-stage trial, and the herbal formula may work no better than placebo. Herbal products can also cause side effects or interact with other medications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 74 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2023

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years of age or above (Chinese subjects only); * Persistent symptoms of pharyngitis (sore throat, globus, dry throat, dry cough, throat irritation) for more than 3 weeks; * Determined to be the following Chinese medicine syndromes by Registered Chinese Medicine Practitioners (RCMPs): Wind-heat invading the upper-jiao, or phlegm heat or Yin deficiency; * Visual analog scale (VAS) score for pain ≥ 50 mm; * Numeric rating scale (NRS) ≥ 6; and * Be able to give voluntary written informed consent. Exclusion Criteria: * Known severe medical conditions, such as cardiovascular, liver or renal dysfunction, diabetes mellitus, cancers, cerebrovascular diseases, blood system diseases; * Concomitant use of steroids, nonsteroidal anti-inflammatory drugs (NSAIDs), anticoagulants, and immunotherapy within the past week; * Impaired hematological profile and liver / renal function exceed the upper limit of the reference value by 2 times; * Known Allergic rhinitis; * Known Gastroesophageal Reflux Disease (GERD); * Known cancer or suspected cancer of throat/oesophagus; * Mechanical obstruction of the throat accountable for the symptoms; * Known alcohol and/or drug abuse; * Known allergic history to any Chinese herbal medicines; and * Subjects who are known pregnant or lactating.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic pharyngolaryngitis (disorder)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hong Kong Institute of Integrative Medicine

    RECRUITING

    Hong Kong, Hong Kong