Heart flutters: which treatment works best?

NCT ID NCT07445334

Disease control Sponsor: Western Sydney Local Health District Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study compares two treatments for premature ventricular complexes (PVCs) — extra heartbeats that can cause symptoms. One treatment is catheter ablation, a procedure that destroys the tiny spot causing the extra beats. The other is medication to control the rhythm. The study will enroll 40 adults with frequent PVCs and follow them for 6 months to see which approach better reduces symptoms and improves quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: catheter ablation (a procedure that destroys the tiny area of heart tissue causing extra beats) and anti-arrhythmic drugs (medication to control heart rhythm)
What this could lead to: If this pilot succeeds, it could point toward a more effective treatment for PVCs, potentially reducing symptoms and improving quality of life without lifelong medication.
What could go wrong: This is a very small pilot study (40 people) that hasn't started yet. It may not show a clear winner, and results may not apply to everyone with PVCs. Catheter ablation carries risks like bleeding or heart damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Premature ventricular complex burden of at least 10%, as determined by multiday (\>24-hour) heart rhythm monitoring * Normal left ventricular ejection fraction * Aged ≥18 years. Exclusion Criteria: * Unable or unwilling to provide informed consent or comply with study requirements including study investigations and follow-up, medical adherence, completion of intervention. * Women who are pregnant or breast feeding. * Life expectancy ≤ 12 months. * Ventricular tachycardia (VT) that is inducible lasting 10 seconds or more; spontaneously occurring lasting 30 seconds or more or not hemodynamically tolerated); or 10 or more episodes of non-sustained ventricular tachycardia (defined as more than five sequential beats, lasting no more than 10 seconds) in 24 hours during ambulatory heart rhythm recording. * Structural heart disease including clinically significant coronary artery, valvular disease or clinically significant myocardial replacement. * Known cardiac channelopathies (e.g. Catecholaminergic polymorphic ventricular tachycardia (CPVT), long- or short QT syndrome, Brugada syndrome). * Responsible primary care or other responsible physician believes it is not appropriate to participate in the study or unable to complete the study procedures, e.g. concomitant illness, physical impairment or mental condition which could interfere with the conduct of the study including outcome assessments.

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Conditions

The condition(s) this trial relates to.

Ventricular Premature Complexes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Premature ventricular beats Premature ventricular complexes Premature ventricular contraction (PVC)

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Heart flutters: which treatment works best?

What the study statuses mean