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Psoriatic arthritis drug showdown: which treatment do patients stick with?

NCT ID NCT05049798

Knowledge-focused Sponsor: Janssen Pharmaceutica N.V., Belgium Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 4 times

Summary

This study follows over 1,300 people with psoriatic arthritis who are starting either guselkumab (Tremfya) or an IL-17 inhibitor as part of their routine care. Researchers will track how long patients continue each treatment and monitor joint swelling and tenderness. The goal is to see which therapy patients stay on longer in real life, not in a controlled lab setting.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
guselkumab (Tremfya) and IL-17 inhibitors
What this could lead to
If successful, this study could help doctors understand which treatment patients stick with longer, improving real-world care for psoriatic arthritis.
What could go wrong
This is an observational study, not a controlled trial, so results may be influenced by patient choices or other factors. It won't prove one drug is better than another.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

1,314 people

The number who actually took part.

Started

Aug 2021

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of participants initially treated for Psoriatic Arthritis (PsA) with guselkumab or interleukin-17 inhibitor (IL-17i) per routine clinical practice in accordance with clinical guidelines.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Main study: * Have a confirmed diagnosis of PsA as determined by a rheumatologist with reference to Classification criteria for Psoriatic Arthritis (CASPAR) * Start guselkumab or any approved interleukin-17 inhibitor (IL-17i) as a first, second, third, or fourth line of biologic disease-modifying antirheumatic drugs (bDMARD) therapy for the indication of PsA as part of standard clinical practice (according to local label, local regulations, and/or reimbursement requirements) at the time of enrollment into the observational study or within a maximum of 2 months after the initial baseline visit or after repeated baseline data collection * Sign a participation agreement/Informed consent form (ICF) allowing data collection and source data verification in accordance with local requirements * Able to read, understand, and intend to comply with completion of all Electronic patient-reported outcome (ePRO) instruments * The treatment decision must be taken by the participating rheumatologist prior to, and independently of the participant's inclusion into the study, following clinical practice in accordance with local and overarching guidelines and local regulations Substudy: * Must sign the substudy ICF allowing data collection in accordance with local requirements * Is scheduled to receive guselkumab or IL-17i, per routine clinical practice, in the main study * Currently using or is willing to use wearables and/or commercial applications to track their disease within the course of their normal daily activities Exclusion Criteria: Main study: * Start guselkumab or an IL-17i therapy as fifth or further line of biologic treatment * Have already taken a specific IL-17i or IL-23i treatment and are planning on re-taking that specific treatment again * Unwilling or unable to participate in long-term data collection * Received an investigational drug (including investigational vaccines) or used an invasive investigational medical device within 30 days before the start of the study (that is, signing of informed consent) * Currently enrolled in any interventional study or any Janssen-sponsored observational clinical study (contemporary participation into observational studies or registries not sponsored by Janssen is acceptable) Substudy: * Have an insufficient command of language to interact effectively with the smartphone application, in the opinion of the investigator at each site * Any condition for which, in the opinion of the investigator, participation would not be in the best interest of the patient (example, compromise the well-being) or that could prevent, limit, or confound assessment * Unwilling or unable to comply with substudy assessments

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Conditions

The condition(s) this trial relates to.

psoriatic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arthritis, psoriatic

Contacts and locations

Locations

  • 'Agios Andreas' General Hospital of Patras

    Pátrai, 263 32, Greece

  • AOU Careggi

    Florence, 50141, Italy

  • AZ Sint-Jan

    Bruges, 8000, Belgium

  • Academisch Medisch Centrum Universiteit van Amsterdam

    Amsterdam, 1105 AZ, Netherlands

  • Akademiska Sjukhuset

    Uppsala, 75185, Sweden

  • Akademiskt Specialistcentrum centrum för reumatologi

    Stockholm, 113 65, Sweden

  • Artus Health Centre

    Vancouver, British Columbia, V5Z 1J9, Canada

  • Athens Navy Hospital

    Athens, 11521, Greece

  • Azienda Ospedaliera Città della Salute e della Scienza di Torino

    Torino, 10126, Italy

  • Azienda Ospedaliera Universitaria Federico II

    Naples, 80131, Italy

  • Azienda Ospedaliera Universitaria Integrata Verona

    Verona, 37067, Italy

  • Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari

    Bari, 70124, Italy

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, 56126, Italy

  • Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone

    Palermo, 90127, Italy

  • Azienda Ospedaliero Universitaria S.Maria Della Misericordia

    Udine, 33100, Italy

  • BIOMAB

    Bogotá, Colombia

  • Bakoulev Scientific Center For Cardiovascular Surgery Rams

    Moscow, 121552, Russia

  • Brandusa Florica Medicine Professional Corporation

    Mississauga, Ontario, L5A 3V8, Canada

  • CHR Orléans - Nouvel Hôpital Orléans La Source

    Orléans, 45032, France

  • CHRU HOPITAL ROGER SALENGRO Consultation Appareil locomoteur

    Lille, 59037, France

  • CHRU Hôpital de Hautepierre

    Strasbourg, 67098, France

  • CHU Grenoble

    Échirolles, 38130, France

  • CHU de Liège - Domaine Universitaire du Sart Tilman

    Liège, 4000, Belgium

  • CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont

    Montreal, Quebec, H1T 2M4, Canada

  • Central Manchester University Hospitals NHS Foundation Trust

    Manchester, M13 9WL, United Kingdom

  • Centre Hospitalier Universitaire(CHU) - Hopital Henri Mondor

    Créteil, 94000, France

  • Centre Hospitalier de Cholet

    Cholet, 49300, France

  • Centre Orthopedique Santy

    Lyon, 69008, France

  • Centre de Recherche Musculo Squelettique

    Trois-Rivières, Quebec, G9A 3X2, Canada

  • Centre de sante et services sociaux (CSSS) de Rimouski-Neigette - Hopital regional - Rimouski

    Rimouski, Quebec, G5L 5T1, Canada

  • Chang Gung Medical Foundation

    Kaohsiung City, 83301, Taiwan

  • City Hospital #3

    Tomsk, 634045, Russia

  • Clinica Vascular las Americas

    Medellín, 50025, Colombia

  • Clinique de l'Infirmerie Protestante de Lyon

    Lyon, 69300, France

  • Clinisalud del Sur

    Medellín, 50012, Colombia

  • Community Rheumatology Care

    Saskatoon, Saskatchewan, S7K 0H6, Canada

  • Complejo hospitalario de Granada

    Granada, 18016, Spain

  • Consultorio de Reumatologia

    México, 07760, Mexico

  • Dr Sabeen Anwar Medicine Professional Corporation

    Windsor, Ontario, N8X 1T3, Canada

  • Dr. Juris Lazovskis Incorporated

    Coxheath, Nova Scotia, B1L 1B3, Canada

  • Elkerliek Ziekenhuis

    Helmond, 5707 HA, Netherlands

  • Evang. Krankenhaus Gemein. Betriebgesm. Mbh

    Vienna, A-1100, Austria

  • Evangelismos General Hospital of Athens

    Athens, 10676, Greece

  • FGBU Research Institute of Rheumatology named V.A.Nasonova

    Moscow, 190068, Russia

  • Footscray Hospital, Western Health

    Footscray, Australia

  • Funcentra

    Montería, 230002, Colombia

  • G R M O Groupe de recherche en maladies osseuses Inc

    Québec, Quebec, G1V 4K5, Canada

  • General Hospital 'Gennimatas'

    Athens, 11527, Greece

  • Glasgow Royal Infirmary

    Glasgow, 650029, United Kingdom

  • HFR Fribourg - Hôpital Cantonal

    Fribourg, 1708, Switzerland

  • Haywood Hospital

    Staffordshire, ST6 7AG, United Kingdom

  • Hippokration General Hospital of Athens, B' Internal Medicine Clinic,

    Athens, 11527, Greece

  • Hokkaido University Hospital

    Sapporo, 060-8648, Japan

  • Hopital Erasme

    Brussels, 1070, Belgium

  • Hopital Pitie Salpetriere

    Paris, 75651, France

  • Hopital Purpan

    Toulouse, 31059, France

  • Hopital Saint-Antoine

    Paris, 75012, France

  • Hosp Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hosp Reina Sofia

    Córdoba, 14004, Spain

  • Hosp Univ A Coruna

    A Coruña, 15006, Spain

  • Hosp Univ Vall D Hebron

    Barcelona, 8035, Spain

  • Hosp. Clinico Univ. de Santiago

    Santiago de Compostela, 15706, Spain

  • Hosp. Punta de Europa

    Algeciras / Cadiz, 11207, Spain

  • Hosp. Univ. 12 de Octubre

    Madrid, 28041, Spain

  • Hosp. Univ. Central de Asturias

    Oviedo, 33011, Spain

  • Hosp. Univ. de Basurto

    Bilbao, 48013, Spain

  • Hosp. Univ. de Getafe

    Madrid, 28905, Spain

  • Hosp. Virgen Del Rocio

    Seville, 41013, Spain

  • Hospital Cordoba

    Córdoba, 5000, Argentina

  • Hospital Italiano de Buenos Aires

    Buenos Aires, C1199ABB, Argentina

  • Hospital J. M. Ramos Mejía

    Buenos Aires, C1221ADC, Argentina

  • Hospital Puerta de Hierro

    Zapopan, 45116, Mexico

  • Hull Royal Infirmary

    Hull, HU3 2JZ, United Kingdom

  • Hôpital Avicenne

    Bobigny, 93000, France

  • Hôpital Bichat

    Paris, 75018, France

  • Hôpital Gabriel Montpied

    Clermont-Ferrand, 63003, France

  • Hôpital Lariboisière - Centre Viggo Petersen

    Paris, 75010, France

  • Hôpital Saint Roch

    Nice, 6006, France

  • Immunologisches Zentrum Vogelsang-Gommern GmbH

    Vogelsang-Gommern, 39245, Germany

  • Ippokrateio Hospital

    Thessaloniki, 546 42, Greece

  • Istituto Clinico Humanitas

    Rozzano, 20156, Italy

  • Kaohsiung Veterans General Hospital

    Kaohsiung City, 81362, Taiwan

  • Kepler Universitatsklinikum GmbH

    Linz, 4021, Austria

  • Kita-harima Medical Center

    Hyōgo, 6751392, Japan

  • Knappschaftsklinikum Saar GmbH Klinik für Rheumatologie

    Püttlingen, 66346, Germany

  • Krankenhaus Porz am Rhein

    Cologne, 51149, Germany

  • Kyorin University Hospital

    Tokyo, 181 8611, Japan

  • LKH-Univ. Klinikum Graz

    Graz, 8036, Austria

  • Laiko General Hospital of Athens

    Athens, 11527, Greece

  • Leeds Teaching Hospitals NHS Trust Chapel Allerton Hospital

    Leeds, LS7 4SA, United Kingdom

  • MR Medicina Reumatologica

    San Fernando, B1646, Argentina

  • Manitoba Clinic

    Winnipeg, Manitoba, R3A 1M3, Canada

  • Markham Rheumatology Hub

    Markham, Ontario, L3R 2C7, Canada

  • Medical Care & Research SA de CV

    Mérida, 97070, Mexico

  • Medisch Spectrum Twente

    Enschede, 7500 KA, Netherlands

  • Medizinische Universitaet Wien

    Vienna, 1090, Austria

  • NHS Grampian - Aberdeen Royal Infirmary (ARI)

    Aberdeen, AB25 2ZB, United Kingdom

  • Nevill Hall Hospital

    Abergavenny, NP7 7EG, United Kingdom

  • OMI

    Buenos Aires, C1015ABO, Argentina

  • Osaka Metropolitan University Hospital

    Osaka, 545 8586, Japan

  • Ospedale Regionale Cardarelli-Università degli Studi del Mol

    Campobasso, 86100, Italy

  • Ospedale San Carlo Di Potenza - Azienda Ospedaliera Regionale

    Potenza, 85100, Italy

  • Praxis Thilo Klopsch

    Neubrandenburg, 17033, Germany

  • Praxis fur Klinische Studien und Praxis fur Orthopadie

    Hamburg, 22415, Germany

  • Praxis für Rheumatologie

    Amberg, 92224, Germany

  • Praxiszentrum St. Bonifatius

    München, 81541, Germany

  • Private Practice - Dr. Pauline Boulos

    Dundas, Ontario, L9H 1B7, Canada

  • Public Interest Incorporated Foundation Nipoon Life Saiseikai Nippon Life Hospital

    Osaka, 550 0006, Japan

  • Queen Alexandra Hospital

    Portsmouth, PO6 3LY, United Kingdom

  • Reumaclinic Genk-Hasselt

    Genk, 3600, Belgium

  • Rheuma-Praxis Bayreuth

    Bayreuth, 95444, Germany

  • Rheumapraxis Dr. Liebhaber

    Halle, 6128, Germany

  • Rheumatologie im Struenseehaus

    Hamburg, 22767, Germany

  • Rheumatologisch-immunologische Arztpraxis

    Templin, 17268, Germany

  • Rheumatologische Praxis

    Magdeburg, 39104, Germany

  • Rheumatologische Praxis 1

    Leipzig, 04109, Germany

  • Rheumatologische Schwerpunktpraxis

    Berlin, 12161, Germany

  • Rheumatologische Schwerpunktpraxis 1

    Berlin, 13055, Germany

  • Rheumatology Associates of Saskatoon

    Saskatoon, Saskatchewan, S7K 0H6, Canada

  • Rheumazentrum Ratingen

    Ratingen, 40878, Germany

  • Rheumazentrum Ruhrgebiet

    Herne, 44649, Germany

  • Royal Free London NHS Foundation Trust Barnet Hospital

    Barnet, EN5 3DJ, United Kingdom

  • Royal North Shore Hospital

    St Leonards, 2065, Australia

  • SBEU HPE Kemerovo State Medical Academy

    Kemerovo, G4 0SF, Russia

  • Sahlgrenska Universitetssjukhuset

    Gothenburg, 41345, Sweden

  • Seconda Univesità degli Studi di Napoli, AOU

    Naples, 80131, Italy

  • Seoul Metropolitan Government Seoul National University Boramae Medical Center

    Seoul, 07061, South Korea

  • Seoul National University Bundang Hospital

    Seongnam, 13620, South Korea

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Service Rheuma Erfurt

    Erfurt, 99096, Germany

  • Servimed S A S

    Bucaramanga, Colombia

  • Shirley Caldwell

    Salford, M6 8HD, United Kingdom

  • Soonchunhyang University Cheonan Hospital

    Cheonan-si, 31151, South Korea

  • Southampton General Hospital

    Southampton, SO16 6YD, United Kingdom

  • St. Claire's Mercy Hospital - Rheumatology Research

    St. John's, Newfoundland and Labrador, A1C 5B8, Canada

  • Stamford and Rutland hospital

    Stamford, PE9 1UA, United Kingdom

  • Taichung Veterans General Hospital

    Taichung, Taiwan

  • The Newcastle upon Tyne Hospitals NHS Trust - Freeman Hospit

    Newcastle upon Tyne, NE7 7DN, United Kingdom

  • The Ottawa Hospital Research Institute

    Ottawa, Ontario, K1H 7W9, Canada

  • The Queen Elizabeth Hospital

    Adelaide, 5011, Australia

  • The Waterside Clinic

    Orillia, Ontario, L3V 1T5, Canada

  • Toho University Medical Center, Ohashi Hospital

    Meguro-ku, 153-8515, Japan

  • UZ Leuven

    Leuven, 3000, Belgium

  • Universita Cattolica del Sacro Cuore

    Rome, 20123, Italy

  • Universita della Magna grecia

    Catanzaro, 88100, Italy

  • Universitair Medisch Centrum Groningen

    Groningen, 9700 RB, Netherlands

  • Universitatsklinikum Dusseldorf

    Düsseldorf, 40225, Germany

  • Universitatsklinikum Frankfurt

    Frankfurt, 60590, Germany

  • Universitetssjukhuset Orebro

    Örebro, 70185, Sweden

  • Universitetssjukhuset i Lund

    Malmö, 20502, Sweden

  • University General Hospital of Rio Patras

    Pátrai, 26500, Greece

  • University Hospital Monklands

    Airdrie, ML6 0JS, United Kingdom

  • University Hospital of Ioannina

    Ioannina, 45560, Greece

  • Wishaw General

    Wishaw, ML2 0DP, United Kingdom

  • Wolfson Centre Royal United Hospitals

    Bath, BA1 3NG, United Kingdom

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