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New pill could ease joint pain for psoriatic arthritis patients

NCT ID NCT06878404

Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 2 times

Summary

This study tests an experimental drug called JNJ-77242113 (icotrokinra) against a placebo in 552 adults with active psoriatic arthritis who have not tried biologic treatments before. The main goal is to see if the drug reduces joint swelling and tenderness after 16 weeks. Participants must have at least 3 swollen and 3 tender joints and elevated inflammation levels to join.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

552 people

The number who actually took part.

Started

Feb 2025

Expected to finish

Feb 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a diagnosis of psoriatic arthritis (PsA) for at least 3 months before the first administration of study intervention and meet classification criteria for psoriatic arthritis (CASPAR) at screening * Have active PsA as defined by: (a) At least 3 swollen joints and at least 3 tender joints at screening and at baseline (b) C-reactive protein (CRP) greater than or equal to (\>=) 0.1 milligrams per deciliter (mg/dL) at screening from the central laboratory * Have at least 1 of the PsA subsets: distal interphalangeal joint involvement, polyarticular arthritis with absence of rheumatoid nodules, arthritis mutilans, asymmetric peripheral arthritis, or spondylitis with peripheral arthritis * Have active plaque psoriasis with at least one psoriatic plaque of \>= 2 cm diameter or nail changes consistent with psoriasis * A female participant of childbearing potential must have a negative highly sensitive serum pregnancy test (Beta-hCG) at screening and a negative urine pregnancy test at Week 0 prior to administration of study intervention Exclusion Criteria: * Has previously received any biologic disease-modifying antirheumatic drugs (DMARDs) for PsA or psoriasis * Has a history or current signs or symptoms of severe, progressive, or uncontrolled renal, hepatic, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic (with the exception of PsA), psychiatric, genitourinary, or metabolic disturbances * Has known allergies, hypersensitivity, or intolerance to icotrokinra or its excipients * Has other inflammatory diseases that might confound the evaluations of benefit of icotrokinra therapy, including but not limited to rheumatoid arthritis (RA), systemic lupus erythematosus, or lyme disease * Participants with fibromyalgia or osteoarthritis symptoms that, in the investigator's opinion, would have potential to interfere with efficacy assessments

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Conditions

The condition(s) this trial relates to.

psoriatic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arthritis, psoriatic

Contacts and locations

Locations

  • Aarhus University Hospital

    Aarhus N, 8200, Denmark

  • Affiliated Hospital of Jiangsu University

    Zhenjiang, 212001, China

  • Affiliated Hospital of Nantong University

    Nantong, 226001, China

  • All India Institute of Medical Sciences

    New Delhi, 110029, India

  • Altoona Center For Clinical Research

    Duncansville, Pennsylvania, 16635, United States

  • Ambulatorium sp. z o.o.

    Elblag, 82-300, Poland

  • Apollo Hospitals

    Bhubaneswar, 751005, India

  • Apollo Multispeciality Hospital Ltd

    Kolkata, 700054, India

  • Arsema

    Ciudad de Buenos Aires, C1431, Argentina

  • Arthritis and Rheumatism Associates ARA Jonesboro

    Jonesboro, Arkansas, 72401, United States

  • Arthritis and Rheumatology Research Institute

    Allen, Texas, 75013, United States

  • BJC Health

    Parramatta, 2150, Australia

  • Beijing Tong Ren Hospital Capital Medical University

    Beijing, 100730, China

  • Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz

    Gyula, 5700, Hungary

  • Betegapolo Irgalmas Rend Budai Irgalmasrendi Korhaz

    Budapest, 1027, Hungary

  • CCR Ostrava S R O

    Ostrava, 70200, Czechia

  • Centro Medico Privado de Reumatologia Tucuman

    Ciudad de San Miguel de Tucuman, T4000AXL, Argentina

  • Centrum Kliniczno Badawcze

    Elblag, 82-300, Poland

  • Centrum Medyczne All Med

    Krakow, 30-033, Poland

  • Centrum Medyczne Oporow

    Wroclaw, 52-416, Poland

  • Centrum Medyczne Pratia Gdynia

    Gdynia, 81-338, Poland

  • Centrum Medyczne Reuma Park

    Warsaw, 02-665, Poland

  • Chang Gung Memorial Hospital

    Kaohsiung City, 833, Taiwan

  • Charite Universitaetsmedizin Berlin

    Berlin, 10117, Germany

  • Chi Mei Medical Center Yong Kang

    Tainan, 710, Taiwan

  • ClinicMed Daniluk Nowak Spolka Komandytowa

    Bialystok, 15-879, Poland

  • Clinical Research of West Florida

    Tampa, Florida, 33606, United States

  • Consultora Integral de Salud SRL

    Córdoba, CP5000, Argentina

  • Corporacio Sanitari Parc Tauli

    Sabadell, 08208, Spain

  • Cosultorios Reumatologógicos Pampa

    Buenos Aires, 1428, Argentina

  • DermMedica Sp z o o

    Wroclaw, 51-503, Poland

  • Dermed Centrum Medyczne Sp z o o

    Lodz, 90-265, Poland

  • Etyka Osrodek Badan Klinicznych

    Olsztyn, 10-117, Poland

  • Exacta Medica

    Pleven, 5803, Bulgaria

  • FN Motol

    Prague, 150 00, Czechia

  • Fachklinik Bad Bentheim

    Bad Bentheim, 48455, Germany

  • Fortis Hospital

    Noida, 201301, India

  • Frederiksberg Hospital

    Frederiksberg, 2000, Denmark

  • Fukuoka University Hospital

    Fukuoka, 814 0180, Japan

  • Hamburger Rheuma Forschungszentrum II

    Hamburg, 20095, Germany

  • Hosp Regional Univ de Malaga

    Málaga, 29009, Spain

  • Hosp Reina Sofia

    Córdoba, 14004, Spain

  • Hosp Univ A Coruna

    A Coruña, 15006, Spain

  • Hosp Univ Vall D Hebron

    Barcelona, 08035, Spain

  • Hosp. Clinic de Barcelona

    Barcelona, 8036, Spain

  • Hosp. Infanta Luisa

    Seville, 41010, Spain

  • Hosp. Quiron Sagrado Corazon

    Seville, 41013, Spain

  • Hosp. Univ. 12 de Octubre

    Madrid, 28041, Spain

  • Hosp. Univ. Marques de Valdecilla

    Santander, 39008, Spain

  • Hosp. Virgen Del Rocio

    Seville, 41013, Spain

  • Hosp. Virgen Macarena

    Seville, 41009, Spain

  • Hospital Central Militar Cirujano Mayor Dr Cosme Argerich

    Buenos Aires, C1426BOS, Argentina

  • Huashan Hospital Fudan University

    Shanghai, 200040, China

  • ISA - Interdisciplinary Study Association GmbH

    Berlin, 10789, Germany

  • Indraprastha Apollo Hospital

    New Delhi, 1100776, India

  • Instituto Medico De Alta Complejidad (IMAC)

    San Isidro, B1642IPN, Argentina

  • Integral Rheumatology And Immunology Specialists

    Plantation, Florida, 33324, United States

  • Ipswich Hospital

    Ipswich, 4305, Australia

  • JSS Hospital

    Mysuru, 570004, India

  • Jiangxi Provincial Peoples Hospital

    Nanchang, 330006, China

  • Johannes Wesling Klinikum Minden

    Minden, 32429, Germany

  • Joint and Muscle Research Institute

    Charlotte, North Carolina, 28204, United States

  • Kagawa University Hospital

    Kita Gun, 761 0793, Japan

  • Kokilaben Dhirubhai Ambani Hsp And Med Research Inst

    Mumbai, 400053, India

  • Kyorin University Hospital

    Tokyo, 181 8611, Japan

  • L K N Arthrocentrum

    Hlučín, 748 01, Czechia

  • Linkou Chang Gung Memorial Hospital

    Taoyuan, 333, Taiwan

  • Linyi City People Hospital

    Linyi, 276002, China

  • MAV Korhaz es Rendelointezet

    Szolnok, 5000, Hungary

  • MC Medtech Services Ltd

    Haskovo, 6304, Bulgaria

  • MICS Centrum Medyczne Torun

    Torun, 87-100, Poland

  • MICS Centrum Medyczne Warszawa

    Warsaw, 00-874, Poland

  • MR Medicina Reumatologica

    San Fernando, B1646GHP, Argentina

  • MUDr Rosypalova s r o

    Ostrava, 70800, Czechia

  • Maeshima Rheumatology Clinic

    Ōita, 870 0030, Japan

  • Malopolskie Badania Kliniczne Sp z o o

    Krakow, 30-002, Poland

  • Marengo Cims Hospital

    Ahmedabad, 380060, India

  • Medical Center Artmed

    Plovdiv, 4002, Bulgaria

  • Medical Center Teodora

    Rousse, 7012, Bulgaria

  • Medical Plus S R O

    Uherské Hradiště, 68601, Czechia

  • Medizinische Fakultat der Albert Ludwigs Universitat Freiburg

    Freiburg im Breisgau, 79104, Germany

  • Mie University Hospital

    Tsu, 514 8507, Japan

  • Mindout Research

    Buenos Aires, C1417EYG, Argentina

  • NZOZ Lecznica MAK MED S C

    Nadarzyn, 05-830, Poland

  • Nagoya City University Hospital

    Nagoya, 467 8602, Japan

  • Naiara Alvarez MD Integrative Rheumatology of South TX

    Harlingen, Texas, 78550, United States

  • Nanfang Hospital of Southern Medical Hospital

    Guangzhou, 510515, China

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

  • National Taiwan University Hospital Hsin Chu Branch

    Hsinchu, 300, Taiwan

  • Nizams Institute of Medical Sciences

    Hyderabad, 500082, India

  • Obudai Egeszsegugyi Centrum Kft

    Budapest, 1036, Hungary

  • Obudai Egeszsegugyi Centrum Kft 1

    Kaposvár, 7400, Hungary

  • Omega Research Consultants

    DeBary, Florida, 32713, United States

  • Osteo Medic S C Artur Racewicz Jerzy Supronik

    Bialystok, 15-351, Poland

  • PV Medical S R O

    Zlín, 76001, Czechia

  • Peking University Third Hospital

    Beijing, 100191, China

  • Phra Nakhon Si Ayutthaya Hospital

    Phra Nakhon Si Ayutthaya, 13000, Thailand

  • Phramongkutklao Hospital

    Bangkok, 10400, Thailand

  • Pingxiang People's Hospital

    Pingxiang, 337055, China

  • Pratia MCM Krakow

    Krakow, 30-727, Poland

  • Prince of Wales Hospital

    Hong Kong, 000000, Hong Kong

  • Public Interest Incorporated Foundation Nipoon Life Saiseikai Nippon Life Hospital

    Osaka, 550 0006, Japan

  • Qualiclinic Kft

    Budapest, 1134, Hungary

  • Queen Elizabeth Hospital

    South Woodville, 5011, Australia

  • RHEUMA s r o

    Břeclav, 690 02, Czechia

  • Rajavithi Hospital

    Bangkok, 10400, Thailand

  • Regionshospitalet Godstrup

    Herning, 7400, Denmark

  • Revimex Pro s r o

    Karvina Frystat, 73301, Czechia

  • Revita Kft

    Budapest, 1027, Hungary

  • Revmacentrum MUDr Mostera s r o

    Brno-Židenice, 615 00, Czechia

  • Revmatologicka Ordinace

    Prague, 140 00, Czechia

  • Revmatologicky ustav

    Prague, 128 00, Czechia

  • Revmatologie s r o

    Brno, 63800, Czechia

  • Rheumatology Research Unit

    Maroochydore, 4558, Australia

  • Rheumazentrum Ruhrgebiet

    Herne, 44649, Germany

  • Royal Darwin Hospital

    Tiwi, 0810, Australia

  • SIDS Hospital & Research Centre

    Surat, 395002, India

  • Saraburi Hospital

    Changwat Sara Buri, 18000, Thailand

  • Sasebo Chuo Hospital

    Sasebo, 857 1195, Japan

  • Second Affiliated Hospital of Soochow University

    Suzhou, 215000, China

  • Shanghai skin disease hospital

    Shanghai, 200443, China

  • Shanxi Bethune Hospital

    Taiyuan, 030032, China

  • Shenzhen People s Hospital

    Shenzhen, 518020, China

  • Sichuan Provincial Peoples Hospital

    Chengdu, 610072, China

  • Siriraj Hospital

    Bangkok, 10700, Thailand

  • Songklanagarind hospital

    Songkhla, 90110, Thailand

  • Specderm Poznanska sp j

    Bialystok, 15-375, Poland

  • Specjalistyczny gabinet dermatologiczny Aplikacyjno Badawczy Marek Brzewski Pawel Brzewski Spolka Cywilna

    Krakow, 30-002, Poland

  • Studienzentrum Dr Schwarz Germany

    Langenau, 89129, Germany

  • Svendborg Hospital Odense University Hospital

    Svendborg, 5700, Denmark

  • Sydvestjysk Sygehus

    Esbjerg, 6700, Denmark

  • Synexus Magyarorszag Kft

    Budapest, 1036, Hungary

  • Szpital Uniwersytecki nr 2 im dr Jana Biziela w Bydgoszczy

    Bydgoszcz, 85-168, Poland

  • Taipei Veterans General Hospital

    Taipei, 112, Taiwan

  • Teikyo University Hospital

    Itabashi Ku, 173 8606, Japan

  • The Affiliated Hospital of Guizhou Medical University

    Guiyang, 561113, China

  • The First Affiliated Hospital of Chongqing Medical University

    Chongqing, 4000016, China

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, 325000, China

  • The First Bethune Hospital of Jilin University

    Changchun, 130021, China

  • The Second Affiliated Hospital of Nanchang University

    Nanchang, 330008, China

  • The Second Affiliated Hospital of Xi'an Jiaotong University

    Xi'an, 710006, China

  • The Third Hospital of Hebei Medical University

    Shijiazhuang, 050051, China

  • Thomayerova nemocnice

    Prague, 140 59, Czechia

  • Tohoku University Hospital

    Sendai, 980 8574, Japan

  • Universitatsklinikum Carl Gustav Carus Dresden

    Dresden, 01307, Germany

  • Universitatsklinikum Tubingen

    Tübingen, 72076, Germany

  • University of Debrecen

    Debrecen, 4032, Hungary

  • University of Szeged

    Szeged, 6725, Hungary

  • Uno Medical Trials Ltd.

    Budapest, 1152, Hungary

  • Vejle Sygehus

    Vejle, 7100, Denmark

  • Vital Medical Center Orvosi es Fogaszati Kozpont

    Veszprém, 8200, Hungary

  • West China Hospital Sichuan University

    Chengdu, 610041, China

  • Willow Rheumatology and Wellness PLLC

    Willowbrook, Illinois, 60527, United States

  • Xiangya Hospital Central South University

    Changsha, 410008, China

  • Zespol Poradni Specjalistycznych Reumed Filia nr 1

    Lublin, 20-607, Poland

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