Psoriasis breakthrough? single shot may keep skin clear for over a year

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult males or females with a diagnosis of plaque psoriasis for at least 6 months. * Baseline Psoriasis Area Severity Index (PASI) score \> 12. * More than 10% body surface area has plaque psoriasis involvement. * Willingness to forgo other available psoriasis therapies, live vaccines, and pregnancy during the trial. * Ability and willingness to provide informed consent and comply with study requirements. Exclusion Criteria: * Non-plaque forms of psoriasis. * Any previous treatment with agents targeting IL-12 or IL-23, including ustekinumab. * Treatment with biologic agents within previous 3 months prior to visit 0, including adalimumab, etanercept, and infliximab. * Treatment with immunosuppressive medications, including methotrexate, cyclosporine, oral retinoids, prednisone, or phototherapy within previous 4 weeks prior to visit 0. * Topical psoriasis treatment within previous 2 weeks prior to visit 0, including topical corticosteroids, vitamin D analogues, retinoids, calcineurin inhibitors, salicylic acid, and coal tar. * Any investigational study medication within previous 6 months prior to visit 0. * History of recent or ongoing uncontrolled bacterial, viral, fungal, or other opportunistic infections. * Positive QuantiFERON-TB Gold test. PPD tuberculin test may be substituted for QuantiFERON-TB Gold test. * Receipt of a live vaccine (e.g., varicella, measles, mumps, rubella, cold-attenuated intranasal influenza vaccine, and smallpox) in the previous 6 weeks prior to visit 0. * Females who are pregnant, lactating, planning on pregnancy during the study period, or unwilling to use a medically acceptable method of birth control. * Severe, progressive, or uncontrolled renal, hepatic, hematological, gastrointestinal, pulmonary, cardiac, or neurological disease, or any other medical condition that, in the investigator's opinion, places the participant at risk by participating in this study. * Any medical history, including laboratory results, deemed by the investigator to be likely to interfere with their participation in the study, or to interfere with the interpretation of the results, or any social condition that, in the opinion of the Investigator, might pose additional risk to the participant or confound the results of the study.