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Psoriasis-Gum disease link: stress and immune markers under the microscope

NCT ID NCT07158125

Knowledge-focused Sponsor: Recep Tayyip Erdogan University Training and Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study will examine 60 adults with psoriasis to understand why they often have higher rates of gum disease. Researchers will measure immune-related proteins and stress hormones in saliva and gum fluid, and also ask about appearance-related anxiety. The goal is to uncover biological connections that could lead to better dental care for people with psoriasis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal biological links between psoriasis and gum disease, pointing toward better prevention or monitoring strategies.
What could go wrong
This is an early observational study with only 60 participants, so results may not apply broadly. It measures markers, not treatments, so no direct benefit is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2025

An estimate. Start dates often move.

Expected to finish

Apr 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients diagnosed with psoriasis who came to the Periodontology Clinic of Recep Tayyip Erdoğan University Faculty of Dentistry for routine periodontal treatment

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Being between the ages of 18 and 65 * Being diagnosed with psoriasis by a dermatologist * Having at least 20 teeth * Not having received periodontal treatment in the last 6 months * Not having taken antibiotics, steroids, and/or nonsteroidal anti-inflammatory drugs in the last 3 weeks * Not having any autoimmune disease, osteoporosis, or cancer * Not using immunosuppressive drugs, oral contraceptives, or bisphosphonates * Not being pregnant * Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS) * Not using chronic medications that affect periodontal tissues (cyclosporine A, phenytoin) * Not having taken antioxidant supplements in the last 6 months Exclusion Criteria: * \<20 teeth * Any significant oral infection (i.e., herpes or candidiasis) * Oral injuries or bleeding unrelated to periodontitis * Periodontal therapy and antibiotic therapy within the past 3 months * Salivary gland dysfunction * Acute illness (fever, sore throat) * Systemic illness, mental illness, immunosuppressive drugs or immunodeficiency * Pregnancy or breastfeeding * Use of antidepressants

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Conditions

The condition(s) this trial relates to.

periodontitis psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Psoriasis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Periodontology of the Faculty of Dentistry of Recep Tayyip Erdogan University

    Rize, Rize Province, 53200, Turkey (Türkiye)

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