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Could a common painkiller sabotage your knee treatment?

NCT ID NCT07766330

Disease control Sponsor: Federal University of São Paulo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This study tests whether taking ibuprofen after a platelet-rich plasma (PRP) injection changes pain relief and knee function in adults with knee osteoarthritis. Participants receive one ultrasound-guided PRP injection and then take either ibuprofen or acetaminophen for five days. Researchers will compare pain scores, knee function, and the need for extra pain medicine over six months to see if the anti-inflammatory drug interferes with the treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Leukocyte-rich platelet-rich plasma (PRP) injection, followed by either ibuprofen or acetaminophen
What this could lead to
If it works, this could help clarify whether avoiding anti-inflammatory drugs after PRP injections improves long-term knee pain relief and function in osteoarthritis.
What could go wrong
This is a relatively small trial, and results may not apply to everyone. Taking ibuprofen after PRP could also reduce the treatment's effectiveness, or cause stomach or kidney side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 80 years * Knee pain for at least 3 months * Radiographic evidence of knee osteoarthritis classified as Kellgren-Lawrence grade I, II, or III * Ability and willingness to provide written informed consent Exclusion Criteria: * Body mass index of 35 kg/m2 or higher * Pregnancy or breastfeeding * Diabetes mellitus with glycated hemoglobin greater than 6.5% * Hematologic disease, including anemia, coagulopathy, or thrombophilia * Hemoglobin below 11 g/dL * Hematocrit below 33% * Platelet count below 150,000/mm3 * Advanced knee osteoarthritis * Rheumatologic disease * Chronic kidney disease * Respiratory disease, including rhinitis, asthma, or chronic obstructive pulmonary disease * Active or previous oncologic disease, as defined in the protocol * Fibromyalgia * Psychiatric disorder currently under treatment * Substance dependence, including smoking, harmful alcohol use, or other substance use * Use of nonsteroidal anti-inflammatory drugs within the previous 30 days * Use of systemic, intra-articular, topical, or inhaled glucocorticoids within the previous 3 months * Current use of anticoagulant or antiplatelet medication * American Society of Anesthesiologists physical status classification of 3 or higher * Currently receiving disability or sickness-related social security benefits * Inability or unwillingness to provide informed consent or complete the required patient-reported outcome measures

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis, knee

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Disciplina de Medicina Esportiva da UNIFESP

    São Paulo, São Paulo, 04022-002, Brazil

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