Aging gut study: do older adults digest protein differently?
NCT ID NCT06553794
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looked at how aging changes the way the body digests protein and absorbs amino acids. Researchers compared 12 young adults (18-35 years) with 12 older adults (67+ years) using a heavy water method and tissue samples from the small intestine. The goal was to understand age-related gut changes that could affect protein intake and healthy aging.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help design better diets for older adults to improve protein intake and support healthy aging.
- What could go wrong
- This is a small observational study with only 24 participants, so findings may not apply to everyone. It does not test a treatment or intervention.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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24 people
The number who actually took part.
- Started
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Aug 2024
- Finished
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Jun 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged 18-35 years or 67+ years * Body mass index (BMI) between 18.5 and 30 kg/m2 * Regular stool frequency ranging from 1-3 times/day Exclusion Criteria: * History of cardiovascular, respiratory, gastrointestinal, urogenital, neurological, psychiatric, dermatologic, musculoskeletal, metabolic, endocrine, haematological, immunologic disorders, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol, interfere with the execution of the experiment, or potential influence the study outcomes (to be decided by the principal investigator and responsible physician) * Major abdominal surgery interfering with gastrointestinal function (upon judgement of the principal investigator and responsible physician) * Use of medication which limit participation in or completion of the study protocol, interferes with the execution of the experiment, or potential influences the study outcomes (to be decided by the principal investigator and responsible physician) * Use of supplementation (i.e. protein, vitamin, pre- and probiotic supplementation) within 14 days prior to testing * Administration of investigational drugs or participation in any scientific intervention study prior or during the study, which may interfere with this study (upon judgement of the principal investigator and responsible physician) Specific diet (e.g. vegetarian, vegan, gluten free, no diary) within the study period * Planning to lose weight during the study period * Excessive alcohol consumption (defined as \> 14 alcoholic consumptions per week) * Smoking * Drug use * Pregnancy * Lactation * Donated blood three months prior to the test day * No given permission to register participation in electronic patient file at MUMC+ and to add records of gastroduodenoscopy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Maastricht University
Maastricht, Maastricht, Netherlands
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Other studies related to the condition(s) this trial covers.