Can smarter screening cut prostate cancer deaths?
NCT ID NCT07155759
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study follows 7,500 men aged 50-74 to see which prostate cancer screening method works best over time. Some men were invited for a standard PSA test, while others had a newer approach using PSA plus a biomarker test and MRI. Researchers will track prostate cancer deaths, diagnoses, and healthcare use through registries to find out if the advanced screening saves more lives.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could show that combining PSA with biomarkers and MRI is a better way to screen for prostate cancer, potentially reducing unnecessary biopsies and deaths.
- What could go wrong
- This is an observational follow-up study, not a new treatment. Results depend on registry data, which may have limitations, and the screening approach may not reduce mortality as hoped.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 7,500 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2024
- Expected to finish
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Nov 2035
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 to 74 years
- Sex
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Male participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Eligible participants: -Men eligible for the longterm f/u-study arms (experimental and control) are participants in the STHLM3MRI trial. Inclusion Criteria: * Men age 50-74 years without prior diagnosis of prostate cancer (ICD-9 C61). * Permanent postal address in Stockholm * Not a previous participant in the Stockholm3 study (2012-2014) Exclusion Criteria: * Severe illnesses such as metastatic cancers, severe cardio-vascular disease or dementia * Contraindications for magnetic resonance imaging (MRI) eg pacemaker, magnetic cerebral clips, cochlear implants or severe claustrophobia. * Men with a previous prostate biopsy the preceding 60 days before invitation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Karolinska Institutet
Stockholm, Sweden
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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