New study aims to save Kids' lungs: Face-Down position or High-Tech ventilation?

NCT ID NCT03896763

Ongoing Disease control Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Feb 05, 2026 · Last updated May 01, 2026 · Updated 10 times

Summary

This study looks at two treatments for children with severe lung failure (ARDS): placing them face down (prone) or using a special breathing machine (high-frequency oscillation). The goal is to see which method helps kids spend more days off the ventilator within 28 days. About 600 children will take part to find a safer, more effective way to support their recovery.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

American Family Children's Hospital, University of Wisconsin

Madison, Wisconsin, 53792, United States
Ann & Robert Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States
Arkansas Children's Hospital

Little Rock, Arkansas, 72202, United States
Bambino Gesu Children's Hospital (Area Rossa Unit)

Rome, Italy, Italy
Banner Health

Phoenix, Arizona, 85006, United States
Birmingham Children's Hospital

Birmingham, UK, United Kingdom
Bloomberg Children's Center, Johns Hopkins University

Baltimore, Maryland, 21287, United States
CS Mott Children's Hospital

Ann Arbor, Michigan, 48109, United States
Centre Hospitalier Universitaire Sainte Justine

Montreal, Quebec, H3T1C5, Canada
Children's Health Dallas

Dallas, Texas, 75235, United States
Children's Hospital Orange County

Orange, California, 92868, United States
Children's Hospital and Medical Center

Omaha, Nebraska, 68198, United States
Children's Hospital at Oklahoma University Medical Center

Oklahoma City, Oklahoma, 73104, United States
Children's Hospital at Westmead

Sydney, Australia
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19014, United States
Children's Hospital of San Antonio

San Antonio, Texas, 78207, United States
Children's Hospital of Wisconsin

Milwaukee, Wisconsin, 53201, United States
Children's of Alabama

Birmingham, Alabama, 35233, United States
Chonnam National University Hospital

Gwangju, South Korea
Cohen Children's Medical Center

Queens, New York, 11040, United States
Duke Children's Hospital

Durham, North Carolina, 27710, United States
Faculty of Medicine Ramathibodi Hospital

Bangkok, Thailand
Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkok, 10700, Thailand
Hadassah Medical Center

Jerusalem, Israel
Hospital SEPACO

São Paulo, Brazil
Hospital de Pediatría J. P. Garrahan. SAMIC

Buenos Aires, Buenos Aires F.D., C1245AAM, Argentina
Inova Fairfax Medical Campus

Falls Church, Virginia, 22042, United States
Instituto Giannina Gasilini

Genova, Italy
Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96813, United States
King Chulalongkorn Memorial Hospital

Bangkok, 10330, Thailand
LeBonheur Children's Hospital

Memphis, Tennessee, 38103, United States
Medical City Dallas

Dallas, Texas, 75230, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Meyer Children's Hospital

Florence, Italy, Italy
Münster University Hospital

Münster, Germany
Norton Children's Hospital

Louisville, Kentucky, 40202, United States
Penn State Children's Hospital

Hershey, Pennsylvania, 17033, United States
Perth Children's Hospital

Perth, Western Australia, 6840, Australia
Rainbow Children's Hospital

Hyderabad, India
Riley Hospital for Children at IU Health

Indianapolis, Indiana, 46202, United States
Sabara Hospital Infantil

São Paulo, Brazil, Brazil
Shaikh Khalifa Medical City

Abu Dhabi, United Arab Emirates
Stanford Children's Health

Palo Alto, California, 94304, United States
Texas Children's Hospital

Houston, Texas, 77030, United States
UH Rainbow Babies & Children

Cleveland, Ohio, 44106, United States
University Hospital Leicester NHS Trust

Leicester, United Kingdom
University Medical Center Groningen

Groningen, Netherlands
University of Iowa Stead Family Chlldren's Hospital

Iowa City, Iowa, 52242, United States
University of Malaysia Medical Center

Kuala Lumpur, Malaysia

Conditions

Explore the condition pages connected to this study.

ACUTE RESPIRATORY DISTRESS SYNDROME IN CHILDREN