IVF breakthrough? pill could replace daily shots
NCT ID NCT05954962
First seen Mar 29, 2026 · Last updated Jun 22, 2026 · Updated 14 times
Summary
This completed Phase 4 trial tested whether an oral progesterone pill (Seidigestan) can replace daily injections of ganirelix (Astarté) for preventing early ovulation during IVF. The study enrolled 150 healthy egg donors aged 18-33. If the pill works as well as the injections, it could simplify IVF by eliminating the need for painful daily shots.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Instituto Bernabeu
Elche, Alicante, 03206, Spain
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
micronized natural progesterone (Seidigestan) and ganirelix acetate (Astarté)
What this could lead to
If successful, this could show that taking a simple progesterone pill is as effective as daily injections for preventing early ovulation during IVF, making treatment easier for patients.
What could go wrong
This is a completed Phase 4 trial with 150 participants, so results are available but may not apply to all IVF patients. The study only included young, healthy egg donors, so findings may not generalize to older women or those with fertility issues.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.