Fertility study probes best way to give progesterone for embryo transfer prep
NCT ID NCT04499131
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how different doses and methods of giving progesterone (vaginal, under the skin, or muscle injection) affect the structure and function of the uterine lining in women preparing for embryo transfer. 109 healthy women with regular cycles took part, and researchers compared their uterine lining to a natural cycle without extra progesterone. The goal was to understand which approach works best, but no embryos were transferred during the study.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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109 people
The number who actually took part.
- Started
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Dec 2021
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 35 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria All women with no history of infertility who agree to participate in the study: 1. Age: 18-35 years old, both inclusive 2. Regular menstrual cycles 3. In good health and not suffering from any mental or medical condition(s) that would preclude participation in the study. Exclusion Criteria Subjects who meet one or more of the following will not be considered eligible to participate in the pilot study: 1. Simultaneous participation in other clinical studies that, at the researcher's criteria, could interfere with the results of this study. 2. Taking oral contraceptives in the three months prior to signing informed consent. 3. Presence of uterine pathology (submucosal or intramural myomas \>4 cm deforming cavity, endometrial polyps or müllerian anomalies) or adnexal pathology (communicating hydrosalpinx). 4. Background of thrombosis, breast cancer, systemic diseases. 5. Those unable to comprehend the investigational nature of the proposed study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Instituto Valenciano de Infertilidad Spain
Valencia, Valencia, 46015, Spain
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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