Probiotic cocktail shows promise in battling recurrent UTIs
NCT ID NCT06857565
First seen Jun 27, 2026 · Last updated Aug 19, 2026 · Updated 6 times
Summary
This study tested whether taking a specific probiotic (Lactobacillus crispatus M247) along with another probiotic blend could help prevent repeat urinary tract infections (UTIs) in women. 84 women with a history of frequent UTIs took either the probiotic combo or a standard probiotic alone for up to 90 days. Researchers tracked how many UTIs occurred over the next year to see if the extra probiotic made a difference.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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84 people
The number who actually took part.
- Started
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Mar 2025
- Finished
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Apr 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult women aged 18-65 years. * History of recurrent urinary tract infections (rUTIs), defined as ≥3 episodes in the past year or ≥2 episodes in the past 6 months. * Able to provide informed consent and comply with study procedures. Exclusion Criteria: * Age \<18 years. * Ongoing complicated cystitis or uncomplicated pyelonephritis. * History of urological abnormalities or kidney stones. * Recent sexually transmitted infection or bacterial vaginosis, or history of recurrent bacterial vaginosis. * Risk factors for sexually transmitted diseases. * Ongoing pregnancy, planning pregnancy, or breastfeeding. * Diagnosis of diabetes mellitus. * Diagnosis of HIV infection or other immunocompromised states. * Recent history of drug or alcohol abuse. * Persistent symptoms and/or pyuria after acute UTI treatment. * Uterine, cervical, vaginal, or urethral cancer. * Urethral diverticulum. * Tuberculous, radiation-induced, cyclophosphamide-induced, or chemical cystitis. * Benign or malignant bladder tumors. * Recent diagnosis of vaginitis. * Known hypersensitivity to study products. * Failure to provide informed consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Complex Operating Unit of Surgical Gynecology and Pelvic Floor Reconstructive Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Rome (RM), 00168, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New symptom diaries aim to improve daily tracking of recurrent UTIs, especially for seniors
- Could fewer antibiotics be better for older women with urinary symptoms?
- Could a probiotic plus smart antibiotic use end the cycle of recurrent UTIs in children?
- Scientists create first tools to measure recurrent UTI burden
- Simple sugar may shield catheter users from painful infections