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Probiotic cocktail shows promise in battling recurrent UTIs

NCT ID NCT06857565

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 19, 2026 · Updated 6 times

Summary

This study tested whether taking a specific probiotic (Lactobacillus crispatus M247) along with another probiotic blend could help prevent repeat urinary tract infections (UTIs) in women. 84 women with a history of frequent UTIs took either the probiotic combo or a standard probiotic alone for up to 90 days. Researchers tracked how many UTIs occurred over the next year to see if the extra probiotic made a difference.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

84 people

The number who actually took part.

Started

Mar 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult women aged 18-65 years. * History of recurrent urinary tract infections (rUTIs), defined as ≥3 episodes in the past year or ≥2 episodes in the past 6 months. * Able to provide informed consent and comply with study procedures. Exclusion Criteria: * Age \<18 years. * Ongoing complicated cystitis or uncomplicated pyelonephritis. * History of urological abnormalities or kidney stones. * Recent sexually transmitted infection or bacterial vaginosis, or history of recurrent bacterial vaginosis. * Risk factors for sexually transmitted diseases. * Ongoing pregnancy, planning pregnancy, or breastfeeding. * Diagnosis of diabetes mellitus. * Diagnosis of HIV infection or other immunocompromised states. * Recent history of drug or alcohol abuse. * Persistent symptoms and/or pyuria after acute UTI treatment. * Uterine, cervical, vaginal, or urethral cancer. * Urethral diverticulum. * Tuberculous, radiation-induced, cyclophosphamide-induced, or chemical cystitis. * Benign or malignant bladder tumors. * Recent diagnosis of vaginitis. * Known hypersensitivity to study products. * Failure to provide informed consent.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Complex Operating Unit of Surgical Gynecology and Pelvic Floor Reconstructive Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    Rome, Rome (RM), 00168, Italy

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