Can probiotics help obese women balance hormones and lose weight?
NCT ID NCT07013409
First seen Jun 26, 2026 · Last updated Jul 07, 2026 · Updated 2 times
Summary
This study tests whether a daily probiotic blend can improve hormone levels, body composition, and mood in obese women. One hundred women aged 18 to 40 with a BMI of 25 or higher will take either the probiotics or a placebo for three months. Researchers will measure changes in estrogen and other factors to see if the probiotics offer any benefit.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Probiotics (L. rhamnosus LRa05 and L. reuteri LR08)
- What this could lead to
- If it works, this could point toward a natural way to help manage weight and hormone-related issues in obese women.
- What could go wrong
- This is an early-stage trial with no phase, a small sample size, and no guarantee the probiotics will outperform a placebo. Results may not apply to all women.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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102 people
The number who actually took part.
- Started
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Jul 2025
- Finished
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Nov 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age: 18 to 40 years old, female, BMI ≥ 25 kg/m2. * Be willing to receive follow-up during the intervention period. * Be willing to provide two blood, urine and fecal samples during the intervention period. * Be willing to take the compound probiotics by oneself every day during the intervention period. * Have good hearing and be able to hear and understand all instructions during the intervention period. Exclusion Criteria: * Suffering from digestive system diseases, mainly gastrointestinal diseases (celiac disease, ulcerative colitis, Crohn's disease). * Suffering from severe neurological disorders (epilepsy, stroke, severe head trauma, meningitis within the past 10 years, brain surgery, brain tumor, long-term coma - excluding general anesthesia). * Have received/are currently receiving treatment for the following mental illnesses: alcohol/drug/substance abuse dependence, schizophrenia, psychosis, bipolar disorder. * Take medication for depression or low mood. * Suffering from internal organ failure (such as heart, liver or kidney failure, etc.). * Have received radiotherapy or chemotherapy in the past. * Have received general anesthesia surgery/procedures within the past three years, or plan to receive general anesthesia procedures/surgeries within the next three months during this trial. * Have suffered from hepatitis (hepatitis B, hepatitis C), HIV or syphilis in the past.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 462000, China