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Could a daily probiotic dissolve kidney stone risk?

NCT ID NCT06477471

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial is testing whether an oral probiotic supplement, MetProrenes, can safely reduce the risk of kidney stones in adults who have had recurrent stone-related colicky pain. About 14 participants will take the supplement twice a day, and researchers will measure changes in pain levels and urine markers linked to stone formation, such as calcium, oxalate, and pH. The study also tracks safety through blood tests. It's an early, proof-of-science investigation, so the results will show whether this approach is worth pursuing in larger studies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
an oral probiotic supplement called MetProrenes, taken as a slow-release capsule twice daily
What this could lead to
If it works, this could point toward a simple, daily probiotic approach to help prevent kidney stones and reduce the pain of stone-related colic.
What could go wrong
This is a very small, early-stage study with only 14 participants, so results may not apply broadly. The probiotic's effects on stone risk and pain are uncertain, and it may not prove effective.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

14 people

The number who actually took part.

Started

Nov 2024

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. The subject is an adult aged between 18 to 55 years old. 2. The subject has a history of recurrent kidney stone colic or acute episode of colicky pain on clinical examination by Physician. 3. Subject having refrigerator at their home for storage of test product. 4. The subject is willing to provide written informed consent and comply with study procedures, including overnight stay for 24 hours at the study centre during both visits. 5. The subject is willing to abide by the study protocol and restrictions, including abstaining from using any other oral or topical treatments for kidney stone colic during the study period. 6. The subject is in a stable medical condition, not requiring immediate intervention or hospitalization. 7. If the subject is female, she is willing to use a highly effective method of contraception throughout the clinical investigation. 1. Females of childbearing potential must practice and maintain an established method of birth control (e.g., IUD, hormonal implant device/injection, birth control pills, diaphragm, condoms with spermicide, partner vasectomy, or abstinence). 2. Non-childbearing potential females who are surgically sterile, post-menopausal for at least 1 year, or have had a tubal ligation, must have been using hormonal contraception for at least 6 months and agree to continue using the same contraception for the study duration. Exclusion Criteria: 1. The subject has a history of severe renal impairment or chronic kidney disease. 2. The subject is pregnant/lactating, or is planning on become pregnant during the course of the study. 3. The subject has presence of significant medical or psychiatric conditions that may interfere with study participation or interpretation of results. 4. The subject has a history of substance abuse or dependence. 5. The subject has severe systemic complications of viral infections, cardiovascular disorders, neurological disorders, renal disorders, or autoimmune disorders. 6. The subject has participated in clinical studies or received any investigational agent in the previous 30 days. 7. The subject has any condition that, in the investigator's judgment, would compromise the subject's safety or study integrity.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • NovoBliss Research Pvt.Ltd

    Ahmedabad, Gujarat, 382481, India