Could probiotics be the key to lowering uric acid?

NCT ID NCT07141888

Disease control Sponsor: Örebro University, Sweden Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether taking probiotics (with or without extra fiber) every day for 6 weeks can lower uric acid levels in people with hyperuricemia. Researchers will enroll 99 adults with high uric acid and compare the probiotic groups to a placebo. They also aim to figure out who benefits most based on gut bacteria, diet, and genetics, with the goal of creating personalized treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Probiotics (two strains) with or without beta-glucan fiber
What this could lead to: If successful, this could lead to a natural, personalized dietary supplement to help manage high uric acid levels and reduce gout risk.
What could go wrong: This is an early-stage trial with only 99 participants over 6 weeks. Results may not apply to everyone, and the effect on uric acid may be small or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 99 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Signed informed consent prior to any study-related procedures 2. Age 18-80 years old 3. BMI range 17.5-40 kg/m2 4. Blood uric acid above 405 μmol/l (6.8 mg/dl) 5. Willing to abstain from regular consumption of probiotic supplements or food products containing probiotic bacteria (including fermented food and beverages) during the study 6. Willing to abstain from regular consumption of supplements and medications known to alter gastrointestinal function or inflammatory status during the study Exclusion Criteria: 1. Recent (within last month) episode of gout 2. Diagnosis of type 1 diabetes 3. Diagnosed inflammatory bowel disease (IBD) 4. Current diagnosis of psychiatric disease/s or syndromes 5. Current diagnosis of neurodegenerative disease 6. Current pregnancy or breastfeeding 7. History of complicated gastrointestinal surgery 8. (Partial) resection of the small intestine or colon 9. Regular use of urate-lowering treatment (apart from allopurinol) in the month prior to inclusion 10. Oral or intravenous administration of antibiotics and/or corticosteroids in the 4 months prior to inclusion 11. Regular use of any non-steroidal anti-inflammatory drug (NSAID) during the last month prior to inclusion (apart from low-dose acetylsalicylic acid) 12. Consumption of more than 9 standard glasses of alcohol-containing drinks per week and/or more than 4 standard glasses per occasion 13. Regular use of probiotic or prebiotic supplementation in the month prior to inclusion 14. Any condition or intake of medication which could substantially interfere with the outcome of the study, as decided by the principal investigator's discretion

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Conditions

The condition(s) this trial relates to.

gout

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hyperuricemia with or without gout

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names. We don't republish those.

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A doctor treating you

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Could probiotics be the key to lowering uric acid?

What the study statuses mean