Friendly bacteria vs. yeast: can a probiotic stop infections from coming back?
NCT ID NCT07727967
First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time
Summary
This trial tests whether taking a specific probiotic supplement (Lactobacillus crispatus Lc-G22) alongside standard antifungal treatment can help prevent repeat vaginal yeast infections. One hundred women with a history of frequent yeast infections will receive either the probiotic or a placebo for two months. Researchers will track how many women remain infection-free over the following year.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a probiotic supplement containing live Lactobacillus crispatus Lc-G22 bacteria
- What this could lead to
- If effective, this probiotic could offer a simple, non-drug way to reduce the frequency of recurrent yeast infections in women.
- What could go wrong
- This is a small, early-stage trial, and probiotics may not work for everyone. Some people may experience digestive discomfort or other mild side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
100 people
The number who actually took part.
- Started
-
Jul 2022
- Finished
-
Oct 2024
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 50 years
- Sex
-
Female participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18-50 years * Female * History of two or more clinically and mycologically confirmed vulvovaginal candidiasis episodes within the preceding 12 months * Current episode with positive vaginal fungal microscopy (10% KOH wet mount) * Presence of typical clinical symptoms (e.g., vulvar pruritus, abnormal vaginal discharge) and signs * Willing to provide written informed consent Exclusion Criteria: * Severe psychiatric disorders * Long-term (\>4 weeks) use of systemic antibiotics, immunosuppressants, or corticosteroids * Known allergy to clotrimazole or any component of the study product * Diabetes mellitus * Pregnancy or lactation * Use of other probiotic supplements within 4 weeks prior to enrollment * Other conditions deemed unsuitable for participation by the investigator
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Vulvovaginal candidiasis are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The Third Affiliated Hospital of Southern Medical University
Guangzhou, Guangdong, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could women test for yeast infections at home? a swab test takes on the lab
- Zinc gel may outsmart recurring yeast infections
- Can we finally outsmart recurrent yeast infections? a new study investigates
- Fast new swab test could speed up vaginitis diagnosis
- Could a contraceptive gel ward off vaginal infections?
- New vaginal device shows promise for yeast infections in small trial