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Probiotic pill could shield lungs and gut from city smog

NCT ID NCT07418489

Prevention Sponsor: University of Turin, Italy Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a daily probiotic supplement can reduce inflammation and other early signs of harm caused by air pollution. Seventy street market vendors in Turin, Italy, will take either the probiotic or a placebo for 4 months. Researchers will measure blood markers of inflammation, DNA damage, and gut health to see if the supplement offers protection.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
probiotic blend (live and heat-inactivated bacteria)
What this could lead to
If it works, this could point toward a simple dietary supplement that helps protect people from the harmful effects of air pollution.
What could go wrong
This is a small, early-stage trial in healthy adults, so results may not apply to everyone. The supplement may not reduce inflammation or DNA damage as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * BMI 18-27 * Street market vendor working ≥4 days/week (≥3 days at the same market site) * Ability to provide written informed consent Exclusion Criteria: * Chronic respiratory, cardiovascular, oncological, gastrointestinal, immunological or endocrine diseases * Smoking * Pregnancy or breastfeeding * Alcohol or substance abuse * Use of immunosuppressants, antibiotics or antacids within the last 6 months * Known immunodeficiency

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy 70 street market vendors working in highly-polluted areas of turin

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Turin - Department of Public Health and Pediatrics

    Turin, 10126, Italy