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Can a daily lozenge reshape the Mouth's microbiome?

NCT ID NCT07757360

Knowledge-focused Sponsor: University of Zurich Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This study tests whether a daily probiotic lozenge containing Streptococcus salivarius K12 can settle in the mouth and improve oral health. Healthy adults will take one lozenge each day for four weeks and provide saliva and dental plaque samples. Researchers will check if the probiotic colonizes the mouth, how it affects other bacteria and yeast, and whether it lowers inflammatory markers in saliva.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a probiotic lozenge containing Streptococcus salivarius K12
What this could lead to
If it works, this could point toward a simple daily probiotic for better oral health and lower mouth inflammation.
What could go wrong
This is a small, early study in healthy people, so results may not apply broadly. The probiotic may not colonize the mouth or reduce inflammation as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Started

May 2026

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy volunteers * Adults (\> 18 years) * no caries or periodontal disease Exclusion Criteria: Within the last 4 weeks before the trial, intake of... * anti-inflammatory drugs * antimicrobial substances * probiotics

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Oral health

Contacts and locations

Locations

  • Center for Dental Medicine

    Zurich, Canton of Zurich, 8032, Switzerland

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