Can a daily lozenge reshape the Mouth's microbiome?
NCT ID NCT07757360
First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time
Summary
This study tests whether a daily probiotic lozenge containing Streptococcus salivarius K12 can settle in the mouth and improve oral health. Healthy adults will take one lozenge each day for four weeks and provide saliva and dental plaque samples. Researchers will check if the probiotic colonizes the mouth, how it affects other bacteria and yeast, and whether it lowers inflammatory markers in saliva.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a probiotic lozenge containing Streptococcus salivarius K12
- What this could lead to
- If it works, this could point toward a simple daily probiotic for better oral health and lower mouth inflammation.
- What could go wrong
- This is a small, early study in healthy people, so results may not apply broadly. The probiotic may not colonize the mouth or reduce inflammation as hoped.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Center for Dental Medicine
Zurich, Canton of Zurich, 8032, Switzerland
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