Could a daily probiotic soothe your upset stomach?
NCT ID NCT07276009
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether a multi-strain probiotic capsule can reduce common digestive issues like bloating, fullness, and stomach pain in adults with functional dyspepsia. Sixty participants will take either the probiotic or a placebo daily for 60 days and report their symptoms and mood through questionnaires. The goal is to see if the probiotic improves both gut health and emotional well-being.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2026
An estimate. Start dates often move.
- Expected to finish
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May 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age 18-65 years 2. Diagnosis of Functional Dyspepsia based on Rome IV criteria, with symptoms present for at least 3 months, and symptom onset at least 6 months before diagnosis, including: * Postprandial fullness * Early satiation * Epigastric pain or burning * (with no evidence of structural disease explaining symptoms) 3. Moderate to severe symptom severity at baseline, as defined by a validated scale (e.g., NDI or global symptom score) 4. Normal upper GI endoscopy within the last 12 months (or at screening), excluding structural disease (e.g., peptic ulcer, malignancy) 5. Negative for H. pylori (either previously treated successfully or tested negative within study screening) 6. Ability and willingness to provide informed consent and comply with study procedures 7. Stable medication use, if any, for at least 4 weeks before screening (e.g., PPIs, antidepressants, laxatives) Exclusion Criteria: 1. Evidence of structural GI disease (e.g., peptic ulcer, gastric cancer, celiac disease) on recent or screening endoscopy 2. History of gastrointestinal surgery affecting stomach or small intestine (except appendectomy or cholecystectomy) 3. Positive test for H. pylori during screening (or untreated known infection) 4. Current or recent use (within 4 weeks) of antibiotics, pre-, pro- or postbiotics, unless part of study protocol 5. Use of medications affecting GI motility (e.g., prokinetics, opioids, anticholinergics) within 2-4 weeks before enrollment 6. Overlap with other functional GI disorders (except IBS) if they are the dominant complaint, unless your protocol allows overlap 7. Clinically significant psychiatric illness (e.g., major depression, schizophrenia) that may interfere with symptom reporting or adherence 8. Severe systemic or metabolic disease (e.g., uncontrolled diabetes, renal or hepatic failure) 9. Pregnancy or lactation, or intention to become pregnant during the study period 10. Participation in another clinical trial within the past 3 months 11. Known allergy or intolerance to study product components
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
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The official record
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A doctor treating you
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