Could a probiotic help your fatty liver?
NCT ID NCT07378280
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether a probiotic called L. lactis CKDB001 can improve liver enzyme levels in people with nonalcoholic fatty liver disease (NAFLD). 95 adults with mildly elevated liver enzymes took either the probiotic or a placebo daily for 12 weeks. The goal was to see if the probiotic could safely help control the disease.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- L. lactis CKDB001 (a probiotic)
- What this could lead to
- If it works, this could point toward a simple, safe supplement to help manage fatty liver disease by improving liver enzyme levels.
- What could go wrong
- This is a small, early-stage study with no phase designation, so results may not be conclusive. The probiotic may not significantly improve liver health, and benefits might not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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95 people
The number who actually took part.
- Started
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Aug 2021
- Finished
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Nov 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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19 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult men and women aged 19 to 75 years at the time of written consent * Voluntarily provided written consent after receiving sufficient explanation about the study * ALT or AST levels exceed the upper limit of normal, but are five times or less than the upper limit Exclusion Criteria: * Pregnant or breastfeeding women * Women of childbearing potential and men who are unable or unwilling to use appropriate contraception during the study period * Individuals with a history of alcohol abuse or chronic alcohol consumption: Daily alcohol consumption averaging over 30g/day (210g/week) for men or over 20g/day (140g/week) for women * Individuals with viral or other liver diseases that could affect study results: * Individuals with a history of or current drug abuse * Individuals with a history of psychiatric disorders or current psychiatric conditions that may interfere with the study * Individuals with a history of major gastrointestinal surgery (excluding appendectomy, but including gastric resection, gastrointestinal bypass, anastomosis, bariatric metabolic surgeries) * Individuals with severe comorbidities that make them unsuitable for study participation (e.g., heart disease, kidney disease, malignancy, immunosuppression, etc.): * Regular consumption of probiotics, prebiotics, synbiotics, or fermented milk within 4 weeks prior to screening (participation allowed if consumption ceases at least 1 month before study start) * Regular consumption of medications, health supplements, or herbal remedies that may affect liver function or anti-inflammatory responses within 4 weeks prior to screening (participation allowed if consumption ceases at least 1 month before study start) * Use of medications that may cause hepatic steatosis (e.g., amiodarone, tamoxifen, methotrexate, tetracycline, corticosteroids) * Use of medications for treating non-alcoholic fatty liver disease (NAFLD) or steatohepatitis (NASH) within 3 months prior to screening (e.g., thiazolidinediones, vitamin E) * Use of medications that may affect study results (e.g., antipyretic analgesics, NSAIDs, anti-tuberculosis drugs, antibiotics, anticonvulsants, choleretics, liver disease medications) * Use of oral steroids, hormones, or drugs that may affect absorption, metabolism, or excretion of food within 4 weeks prior to screening (participation allowed if taking systemic steroids or thyroid hormones in stable doses for ≥3 months before screening) * Use of hypoglycemic agents or lipid-lowering drugs (except insulin or thiazolidinediones) with stable doses for at least 3 months prior to screening * Dietary or exercise therapies that may affect study within 3 months prior to screening * Smokers consuming more than 20 cigarettes per day * Allergies or digestive issues related to study food ingredients * Weight loss exceeding 10% of previous body weight within 6 months prior to screening * Participation in another clinical trial within 30 days prior to screening or not completing the required five-half-life period of investigational drug/food from a previous trial * Any other individuals deemed unsuitable for the study by the investigator
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hallym University Chuncheon Sacred Heart Hospital
Chuncheon, Gangwon-do, 24210, South Korea
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Other studies related to the condition(s) this trial covers.
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