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Could a daily probiotic keep you regular? new study tests Bi66

NCT ID NCT06740500

Symptom relief Sponsor: Huazhong University of Science and Technology Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking a probiotic called Bifidobacterium animalis subsp. lactis Bi66 every day for 8 months can improve bowel function in healthy adults who have fewer than 5 bowel movements per week. 117 participants took either the probiotic or a placebo and recorded their bowel habits and stool consistency. The researchers also checked changes in gut bacteria and other health markers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Bifidobacterium animalis subsp. lactis Bi66 (a probiotic)
What this could lead to
If it works, this could point toward a simple probiotic supplement to help with occasional constipation or irregular bowel movements.
What could go wrong
This is a small, completed trial in healthy adults, not a treatment for any disease. Results may not apply to people with gut disorders, and benefits may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

117 people

The number who actually took part.

Started

Oct 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18-65 years old; * Self-reported bowel movement frequency less than 5 times per week; * Change of weight no more than 3 kg within the last 2 months； * No consumption of probiotics, prebiotics, synbiotics within the last 2 months Exclusion Criteria: * Pregnant or breastfeeding women； * Smoking； * BMI \< 18 kg/m2 or ≥28 kg/m2； * Suffering from gastrointestinal disorders such as gastroenteritis, gastroduodenal ulcer, ulcerative colitis, Crohn's disease, intestinal stress syndrome, functional diarrhea, gastroparesis, etc； * History of gastrointestinal surgery (except appendectomy or hernia repair)； * Change in dietary habits within the last 1 month (e.g. ketogenic diet, etc.)； * History of major surgery within the last 3 months or major surgery planned in the next 1 month; * Use of antibiotics, acid-suppressing drugs, pro-digestive drugs (gastrointestinal, morpholine, cisapride, etc.), anti-constipation drugs, anti- diarrhea drugs, etc., in the last 1 month; * Participate in a similar intervention study within the last 1 month

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy adult

Contacts and locations

Locations

  • Huazhong University of Science and Technology

    Wuhan, Hubei, 430000, China

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