New combo eye surgery aims to fix thin corneas and improve vision
NCT ID NCT07277348
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tests a procedure called PRK-Plus, which combines laser vision correction with corneal cross-linking to treat thin, suspicious corneas. The goal is to improve vision and strengthen the cornea to prevent future problems. Sixty participants with thin corneas and certain vision issues will be enrolled. The study will measure how much vision improves and how safe the procedure is in the short term.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- PRK-Plus (photorefractive keratectomy combined with accelerated cross-linking)
- What this could lead to
- If successful, this could offer a way to improve vision and stabilize thin corneas, potentially reducing the risk of progression to more serious conditions.
- What could go wrong
- This is a small, early pilot study with no control group, so results may not be conclusive. There are risks from the procedure itself, such as infection or corneal haze.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Feb 2026
An estimate. Start dates often move.
- Expected to finish
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Mar 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. CCT less than 490 microns 2. K mean more than 46 and/or K max more than 47. 3. Astigmatism cylinder \>1.5 D. 4. D value of Belin/Ambrósio Module \> 1.6 5. inferior- superior asymmetry or bow-tie pattern with skewed radial axes on tangential maps and abnormal changes on (BAD). 6. Asymmetry topography between 2 eyes, even if neither eye"s topographic pattern is in itself decidedly abnormal. 7. Any significant skewed radial axis with or without inferior steepening, or one diopter or more of inferior steepening in some areas but an I-S value of ,1.4,7. 8. young patients with against-the-rule astigmatic patterns. 9. a PTA value 40% if calculated. 10. Abnormal Topographic Patterns 11. K2 reading of corneal back surface less than \[-7\]. 12. D Value of CSTP \> 2.5 in Belin/Ambrósio curve 13. We look at values within the central 5 mm circle; the map should be displayed in the BFTE float mode with an estimated area of 8 mm of diameter: * Elevation values on the front surface values \> +12 μ * Elevation values on the back surface values \>+15 μ. * If there is any isolated island on either front or back surfaces (in the BFS float mode) Exclusion Criteria: 1. Eyes diagnosed with KC. 2. CCT less than 450 microns
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.