Simple breathing device may cut lung surgery complications
NCT ID NCT07365072
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding a hand-held breathing muscle trainer to standard pre-surgery exercise rehab can reduce complications and hospital stays for people with lung cancer. About 100 adults scheduled for lung cancer surgery will be split into two groups: one gets standard rehab plus the breathing trainer, the other gets standard rehab alone. Researchers will track complications and recovery for up to 12 months after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Inspiratory muscle training device (POWERBreathe)
- What this could lead to
- If it works, this could reduce serious complications and shorten hospital stays after lung cancer surgery, making recovery easier.
- What could go wrong
- This is a small, early-stage trial with only 100 participants, so results may not apply to everyone. The device may not provide significant benefit over standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2025
- Expected to finish
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May 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 90 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Adults with lung cancer with surgically resectable disease who are referred for pre-treatment optimization with Prehab, from the lung cancer Multi-Disciplinary Teams (MDTs). The referral criteria for Prehab is below: * ≥1 Medical Research Council (MRC) dyspnoea score * ≥1 World Health Organization (WHO) performance status (PS) * Age ≥ 70 years * Frailty index \>3 * Borderline or poor pulmonary function (forced expiratory volume in one second (FEV1) \< 50% or diffusion capacity for carbon monoxide (DLCO) \<50%) * Sedentary people despite having adequate FEV1 or DLCO * People who are eligible for surgical procedures, including endobronchial excision of tumour, or lobectomy, segmental resection, pneumonectomy or wedge resection, either via a minimally invasive approach or a standard thoracotomy approach Additionally: * Participants will be included in the trial if they are capable of providing verbal and written consent for Prehab, and written consent for undergoing a surgical procedure for lung cancer * People over 18 years of age * All people will be considered regardless of their baseline respiratory muscle strength Exclusion Criteria: Inclusion criteria not met * People diagnosed with other cancers namely, metastatic lung cancer, mesothelioma, sarcoma, mediastinal tumours, or benign diseases * People who decline Prehab * People who do not consent to Prehab, and do not attend Prehab. People who do not consent to surgery * People with a high cardiovascular risk for Prehab and awaiting investigations or interventions (including unstable angina and syncope) * People with a serious concomitant disorder that would compromise safety during Prehab * People with an abdominal hernia or recent abdominal surgery * People with a history of spontaneous pneumothorax and/or evidence of large bullae on radiological imaging * People with an inability to understand written and/or spoken English (only if carers are able to translate) * People with a perforated ear drum * People with worsening heart failure signs and symptoms after IMT * People with pulmonary hypertension * People who have suffered from or likely to suffer from costochondritis * If a participant was involved in a similar study, with potential to cause bias or conflict of interest then they will be excluded
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Swansea Bay University Health Board
RECRUITINGSwansea, SA6 6NL, United Kingdom
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