Blood membranes may boost dental implant success in thin jawbones
NCT ID NCT07164417
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed trial tested two types of membranes made from a patient's own blood (PRF and e-PRF) used with bone graft material during dental implant placement in a thin lower jaw. Twenty adults with missing back teeth and a narrow jawbone took part. The study measured implant stability and pain/swelling after surgery to see if one membrane worked better.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Platelet-rich fibrin (PRF) and extended platelet-rich fibrin (e-PRF) membranes used with xenograft bone graft material
- What this could lead to
- If one membrane works better, it could improve dental implant success in people with thin jawbones, reducing the need for more complex bone grafting.
- What could go wrong
- This is a small, single-center trial with only 20 participants, so results may not apply to everyone. The study is completed, but the findings are preliminary and need confirmation in larger trials.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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20 people
The number who actually took part.
- Started
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Oct 2024
- Finished
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Jan 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient with one or more missing posterior mandibular teeth. * Patient with atrophic posterior mandible with residual ridge width in the range of 4 to 6mm. * Patient with good oral hygiene and acceptable inter-arch space less than or equal to the restoration Exclusion Criteria: * The patient underwent alveolar ridge reconstruction in the same area. * Patients with immune diseases, uncontrolled hypertension, and uncontrolled diabetes. * Patient with any pathological condition at the site of surgery. * Heavy smoker, alcohol abuse, parafunctional habits.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Egypt
Alexandria, Azarita, 00203, Egypt