Which blood clot membrane heals teeth best? a Head-to-Head lab test
NCT ID NCT07778160
First seen Aug 21, 2026 · Last updated Aug 21, 2026
Summary
This study compares three types of platelet-rich fibrin (PRF) membranes—made from a person's own blood—to see which releases more growth factors and resists breakdown. Healthy volunteers aged 18 to 40 provide blood samples, from which Albumin-PRF, A-PRF+, and L-PRF are prepared. Researchers measure growth factor levels (VEGF, PDGF, TGF-B) and degradation rates in the lab. The goal is to identify which PRF preparation may be most useful for regenerative dental procedures.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Three types of platelet-rich fibrin (PRF) membranes prepared from participants' own blood: Albumin-PRF, Advanced Platelet-Rich Fibrin+ (A-PRF+), and Leukocyte-Platelet Rich Fibrin (L-PRF).
- What this could lead to
- If one PRF type releases more growth factors or lasts longer, it could become the preferred choice for dental and tissue regeneration procedures.
- What could go wrong
- This is a small laboratory study with healthy volunteers, so results may not directly predict how these membranes perform in real patients or in complex healing situations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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10 people
The number who actually took part.
- Started
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Jan 2026
- Finished
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May 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy volunteers aged 18 to 40 years * Male or female * Able and willing to provide written informed consent * Non-smokers * No history of systemic disease * No regular medication use * No use of antibiotics, corticosteroids, or non-steroidal anti-inflammatory drugs within the previous 6 months Exclusion Criteria: * Age younger than 18 years or older than 40 years * Smoking * Pregnancy or breastfeeding * History of any systemic disease * Regular medication use * Use of antibiotics, corticosteroids, or non-steroidal anti-inflammatory drugs within the previous 6 months * Refusal or inability to provide written informed consent
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Izmir Katip Celebi University Faculty of Dentistry
Izmir, İzmir, 35620, Turkey (Türkiye)