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Which blood clot membrane heals teeth best? a Head-to-Head lab test

NCT ID NCT07778160

Knowledge-focused Sponsor: Izmir Katip Celebi University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This study compares three types of platelet-rich fibrin (PRF) membranes—made from a person's own blood—to see which releases more growth factors and resists breakdown. Healthy volunteers aged 18 to 40 provide blood samples, from which Albumin-PRF, A-PRF+, and L-PRF are prepared. Researchers measure growth factor levels (VEGF, PDGF, TGF-B) and degradation rates in the lab. The goal is to identify which PRF preparation may be most useful for regenerative dental procedures.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Three types of platelet-rich fibrin (PRF) membranes prepared from participants' own blood: Albumin-PRF, Advanced Platelet-Rich Fibrin+ (A-PRF+), and Leukocyte-Platelet Rich Fibrin (L-PRF).
What this could lead to
If one PRF type releases more growth factors or lasts longer, it could become the preferred choice for dental and tissue regeneration procedures.
What could go wrong
This is a small laboratory study with healthy volunteers, so results may not directly predict how these membranes perform in real patients or in complex healing situations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

10 people

The number who actually took part.

Started

Jan 2026

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy volunteers aged 18 to 40 years * Male or female * Able and willing to provide written informed consent * Non-smokers * No history of systemic disease * No regular medication use * No use of antibiotics, corticosteroids, or non-steroidal anti-inflammatory drugs within the previous 6 months Exclusion Criteria: * Age younger than 18 years or older than 40 years * Smoking * Pregnancy or breastfeeding * History of any systemic disease * Regular medication use * Use of antibiotics, corticosteroids, or non-steroidal anti-inflammatory drugs within the previous 6 months * Refusal or inability to provide written informed consent

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRF growth factor release

Contacts and locations

Locations

  • Izmir Katip Celebi University Faculty of Dentistry

    Izmir, İzmir, 35620, Turkey (Türkiye)