Progesterone or pessary: which prevents preterm birth better?
NCT ID NCT02511574
First seen Apr 03, 2026 · Last updated Jun 20, 2026 · Updated 11 times
Summary
This study tested whether natural progesterone or a cervical pessary (a silicone ring placed in the vagina) is better at preventing early birth in pregnant women with a short cervix (25 mm or less). The trial included 203 women with a single baby. Researchers tracked how many gave birth before 34 weeks. The goal is to find the most effective way to reduce preterm births and improve newborn health.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Hospital das Clínicas da Faculdade de Medicina da USP
São Paulo, São Paulo, 05403-000, Brazil
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
natural progesterone (drug) and cervical pessary (device)
What this could lead to
If one option proves clearly better, it could become the standard way to prevent preterm birth in women with a short cervix, reducing health risks for babies.
What could go wrong
This is a single completed study with 203 participants, so results may not apply to all pregnant women. Neither treatment is a guarantee, and some women may still deliver early.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.