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Can a simple stitch help twins stay in the womb longer?

NCT ID NCT07372495

Prevention Sponsor: National Hospital of Obstetrics and Gynecology Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two approaches to prevent preterm birth in women carrying twins who have a short cervix. One group gets a cervical stitch (cerclage) plus vaginal progesterone, while the other gets progesterone alone. Researchers will track which group has fewer births before 28 weeks, aiming to find the best way to protect these babies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cervical cerclage (a stitch to close the cervix) and vaginal progesterone (hormone medication)
What this could lead to
If it works, this could give doctors a better way to prevent early delivery in twin pregnancies, reducing health risks for babies.
What could go wrong
This is a mid-stage trial with 260 participants, so results may not apply to all. The procedure carries small risks like infection or bleeding, and the combination may not be more effective than progesterone alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 260 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

May 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Maternal age ≥ 18 * Twin pregnancy * Asymptomatic short cervix (CL≤30mm) at routine ultrasound investigation * Gestational age at 16+0- 24+0 weeks Exclusion Criteria: A potential paticipant who meets any of the following criteria will be excluded from participation in this trial: * Women with twin pregnancy in which one or both fetuses are diagnosed with a major structural or congenital abnormality that is likely to influence the composite adverse neonatal outcome. * Women with a monochorionic monoamniotic twin pregnancy * A monochorionic twin pregnancy with twin-to-twin transfusion syndrome before or at the time of inclusion. * Patients have indications for vaginal cerclage: Recurrent late miscarriage (from 14 weeks) or preterm birth occurring two or more times. * Women with dilatation of the cervix diagnosed by ultrasound or physical exam * Women with overt symptoms of preterm labor at the time of measurement of the short cervix (regular contractions, PPROM, recurrent blood loss). * Women with the presence of fever ≥ 38 degrees Celsius. * Women with a placenta previa, vasa previa. * Uterine malformations: unicornuate uterus, bicornuate uterus, uterine septum, fibroid… * Severe maternal conditions (heart failure, chronic kidney disease, systemic lupus erythematosus …)

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Conditions

The condition(s) this trial relates to.

Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Preterm

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    6 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Bac Ninh 1 Obstetrics and Pediatrics Hospital, Bac Ninh, Vietnam

    NOT_YET_RECRUITING

    Bac Ninh, 220000, Vietnam

  • Bac Ninh 2 Obstetrics and Pediatrics Hospital, Bac Ninh, Vietnam

    NOT_YET_RECRUITING

    Bac Ninh, 220000, Vietnam

  • Hung Yen Obstetrics and Pediatrics Hospital, Hung Yen, Vietnam

    NOT_YET_RECRUITING

    Hung Yen, 160000, Vietnam

  • National Hospital of Obstetrics and Gynecology

    RECRUITING

    Hanoi, 100000, Vietnam

  • Ninh Binh Obstetrics and Pediatrics Hospital, Ninh Binh, Vietnam

    NOT_YET_RECRUITING

    Ninh Binh, 430000, Vietnam

  • Quang Ninh Obstetrics and Pediatrics Hospital, Quang Ninh, Vietnam

    NOT_YET_RECRUITING

    Quang Ninh, 200000, Vietnam

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