New combo approach aims to stop pneumonia in ventilated patients
NCT ID NCT07555236
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether using two automated devices together—one that drains fluids from above the breathing tube and another that monitors the tube's cuff pressure—can reduce the amount of fluid entering the lungs of critically ill patients on ventilators. The goal is to prevent ventilator-associated pneumonia, a serious infection. 800 adults in intensive care will be randomly assigned to one of four groups to compare the combined approach against each device alone or standard care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to a standard care approach that reduces ventilator-associated pneumonia in intensive care units.
- What could go wrong
- This is an early-stage trial (not yet recruiting) and results may not show a clear benefit over standard care. The outcome is based on enzyme levels, not directly on pneumonia rates.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 800 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Jul 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Adult patients (\> 18 years-old) admitted to the ICU Mechanical ventilation duration expected to be \> 48 h Intubated with a tracheal tube allowing subglottic secretion drainage Exclusion Criteria: Ongoing pregnancy Patients lacking health insurance Patients lacking legal capacity Moribund patients (expected to die in the first 24 h of ICU stay) Patients with specific oropharyngeal conditions (e.g. severe soft tissue infections of the neck, pharyngeal or laryngeal surgery, history of larynx or pharynx irratidation)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.