Foreskin tissue offers new hope for complex ureteral repair
NCT ID NCT07408050
First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 2 times
Summary
This study tests a new surgical technique that uses a piece of foreskin (from circumcision) to repair complex ureteral strictures—narrowing of the tube that carries urine from the kidney to the bladder. The trial will enroll 50 men who cannot be treated with standard surgery. The goal is to see if this graft can safely restore urine flow and protect kidney function.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- preputial graft (foreskin tissue used as a graft for ureteral reconstruction)
- What this could lead to
- If successful, this could provide a safe, minimally invasive surgical option for repairing complex ureteral strictures using tissue that is normally discarded.
- What could go wrong
- This is a small, early-stage study (50 participants) with no control group. The procedure may not work for all types of strictures, and risks include graft failure or complications from surgery.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Jan 2032
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Male participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * Male patients over 18 years of age. * Preoperative assessment confirming complex ureteral strictures, characterized by ureteral luminal stenosis that cannot be addressed via conventional end-to-end anastomosis. Patients were deemed ineligible for existing surgical. interventions such as pyeloureteroplasty, ureteral end-to-end anastomosis, and ureteroneocystostomy. * Ability to undergo minimally invasive laparoscopic surgery for ureteral stricture repair. * Presence of redundant prepuce or availability of an inner preputial flap for graft harvesting. * Capacity for independent decision-making and willingness to voluntarily sign the informed consent form for study participation. Exclusion Criteria * Presence of surgical contraindications. * History of abdominal radiotherapy. * Ureteral strictures resulting from malignant tumors. * An Eastern Cooperative Oncology Group (ECOG) performance status score greater than 2. * Poor compliance or other exclusion criteria as determined by the investigators.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, 430030, China