Blood and swab tests could predict preterm birth risk
NCT ID NCT04067908
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study investigates whether new biomarkers found in blood and vaginal samples can help predict the risk of premature delivery in pregnant women showing signs of preterm labor. Researchers will collect extra blood and swab samples from women between 22 and 33 weeks of pregnancy who are experiencing contractions or cervical changes. The goal is to see if these markers can identify who will deliver before 37 weeks, especially before 34 weeks, to improve early detection and care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to a simple test that helps doctors predict which women are at risk of premature delivery, allowing earlier interventions.
- What could go wrong
- This is an observational study, not a treatment trial. The biomarkers may not prove accurate enough for clinical use, and results may not apply to all pregnancies.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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111 people
The number who actually took part.
- Started
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Jun 2011
- Finished
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Dec 2013
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Pregnant women over 18 years of age * Term from 22 to 33 and 6 amenorrhea weeks * Single or twin pregnancy * Emergency consultant, in participating centers, for a threat of premature labor defined by: Uterine contractions greater than or equal to 3 in 30 minutes Clinical modification of the cervix Ultrasound collar less than 25 mm * Free, informed and written consent, dated and signed by the patient and the investigator before any investigation required by the research. * Patient affiliated to a Social Security scheme. Exclusion Criteria: * Premature rupture of membranes * Placenta previa * Vaginal haemorrhage at the time of sampling * Uterine malformation * Strapping, open bite * History of strapping and or open bite * Conization * Fetal malformation * Associated vasorenal pathology * Sexual intercourse less than 24h * Gynecological examination less than 48h * Vaginal treatment in progress * Polyhydramnios * Transfused-transfused syndrome * Twin Anemia Polycythemia syndrome * Fetoscopy during pregnancy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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