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Can a simple fluid prevent dangerous drops in blood pressure during heart surgery?

NCT ID NCT07329660

Symptom relief Sponsor: Air Force Military Medical University, China Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving a special fluid (colloid) before anesthesia can prevent blood pressure drops in 116 people undergoing transcatheter aortic valve replacement (TAVR). Participants will receive either the colloid or a standard salt solution before anesthesia. The goal is to see which fluid keeps blood pressure more stable during the first 15 minutes after anesthesia starts.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Hydroxyethyl starch 130/0.4 and Lactate Ringer's Solution
What this could lead to
If it works, this could point toward a better way to keep blood pressure stable during TAVR anesthesia.
What could go wrong
This is a small, early-stage trial (116 people) comparing two fluids, not a new treatment. The benefit may be small or not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 116 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years; * Patients scheduled to undergo elective TAVR under general anesthesia; Exclusion Criteria: * Allergy to hydroxyethyl starch, its components, and/or sodium lactate Ringer's solution, or a history of colloidal allergy; * Severe cardiac dysfunction (ejection fraction\[EF\] \< 35%); * Severe renal dysfunction (creatinine \> 132 μg/L and/or requiring renal replacement therapy); * Morbid obesity (body mass index\[BMI\] \> 37.5 kg/m² or \> 32.5 kg/m² with metabolic diseases); * Severe hepatic dysfunction ; * Severe electrolyte disturbances ; * Patients with preoperative intracranial hypertension requiring dehydration therapy; * Expected postoperative hospital stay \< 24 hours; * Patients scheduled for multiple surgeries during this hospitalization.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia induction Hemodynamic stability Transcatheter aortic valve replacement

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.