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Could a Pre-Surgery painkiller make jaw surgery recovery easier?

NCT ID NCT07571252

Symptom relief Sponsor: University of Puerto Rico Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 02, 2026 · Updated 4 times

Summary

This study tests whether giving acetaminophen or ibuprofen before jaw surgery can lower pain after the operation. 72 adults having specific jaw procedures will be split into three groups: one gets IV acetaminophen, one gets IV ibuprofen, and one gets standard care without pre-surgery medication. Researchers will measure pain scores and how much extra pain medicine is needed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
acetaminophen and ibuprofen (given intravenously before surgery)
What this could lead to
If it works, this could point toward a standard way to reduce pain and the need for rescue painkillers after jaw surgery.
What could go wrong
This is a small, early-phase trial (72 people) testing a common approach, so results may not be dramatic or change practice widely. Pain is subjective and hard to measure precisely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 72 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 21 to 65 years. * American Society of Anesthesiologists (ASA) physical status I or II. * Scheduled to undergo orthognathic surgery including bilateral sagittal split osteotomy and Le Fort I osteotomy under general anesthesia. * Ability to understand the study procedures and provide written informed consent. Exclusion Criteria: * Pregnancy or breastfeeding. * Known allergy or intolerance to acetaminophen, ibuprofen, or other nonsteroidal anti-inflammatory drugs (NSAIDs). * Renal dysfunction, defined as estimated glomerular filtration rate \<60 mL/min/1.73 m². * Hepatic dysfunction, defined as liver enzyme levels greater than twice the upper limit of normal. * History of bleeding disorders or coagulopathy. * Active or recent peptic ulcer disease. * Current use of recreational drugs, including cannabis, that in the judgment of the investigators could interfere with anesthesia management, postoperative pain assessment, or study outcomes. * Any medical condition that, in the judgment of the investigators, would make participation unsafe or interfere with study participation.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Orthognathic surgery Post operative pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Administración de Servicios Médicos (ASEM)

    RECRUITING

    San Juan, 00936, Puerto Rico

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