Blood markers may forecast preterm delivery within a week
NCT ID NCT01340222
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 210 pregnant women hospitalized for preterm labor between 24 and 34 weeks. Researchers measured specific immune cells in their blood to see if these could predict whether they would deliver within 7 days. The goal is to find a more accurate way to identify women at highest risk, improving care and reducing unnecessary interventions.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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210 people
The number who actually took part.
- Started
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Mar 2011
- Finished
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Jul 2015
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria for patients: * Threat of preterm labour (PTL) occurring between 24 and 34 WOA, defined according to validated criteria i.e. by (1) the presence of regular uterine contractions, lasting at least 30 seconds at a frequency ≥ 4 contractions every 30 minutes and confirmed by an external tocogram, (2) a cervical dilation of 3 cm or greater, to focus on true preterm labour, for the nulliparous women and 1-3 cm among primiparous women or multiparous and (3) a cervical obliteration \>50%, or a cervix less than 25mm according to the echography, when this information is available. The first two criteria being mandatory, the third one optional as it is more subjective, or less likely to be available for every patient. * Person who has given written consent * Singleton pregnancy Inclusion Criteria for volunteers: * Person who has given written consent * Group 1: Women of reproductive age who have never had a pregnancy, even if not completed to term. * Group 2: Single full-term, uncomplicated pregnancy (= out of hospital) older than 6 months. Exclusion Criteria for patients: * Pre-existing diabetes or gestational diabetes, morbid obesity (BMI \> 35 kg/m2) as these situations modify the expression of MCP-1. * Woman presenting a spontaneous rupture of membranes (SRM) with confirmed or probable chorioamniotitis * Inflammatory or auto-immune disease * Suspected or confirmed infectious disease, including HIV, HCV, HBV * Anti-inflammatory drug treatment or immuno-modulator. * Multiple pregnancies * PTL \<24 WOA or \>34 WOA * Patient less than 18 years of age. * Patient not affiliated to social security insurance Exclusion Criteria for volunteers: * Pre-existing diabètes * Morbid obesity (BMI \> 35 kg/m2) * Inflammatory or auto-immune disease * Suspected or confirmed infectious disease, including HIV, HCV, HBV * Anti-inflammatory drug treatment or immuno-modulator. * Minor person * Person not affiliated to social security insurance * History of twin pregnancy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre d'investigation clinique plurithématique
Dijon, 21079, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.