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Brain zapping gets a precision upgrade

NCT ID NCT06645613

Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a new method to deliver transcranial magnetic stimulation (TMS) more precisely to specific brain networks. Researchers will use MRI scans from 50 healthy adults to map brain connections, then apply TMS to targeted areas while measuring reaction times and brain activity with EEG. The goal is to see if this personalized targeting can improve performance on a computer task, which could eventually lead to better treatments for brain disorders.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcranial magnetic stimulation (TMS) device
What this could lead to
If successful, this could lead to more precise TMS targeting for treating brain disorders like depression or chronic pain.
What could go wrong
This is an early-stage, small study in healthy volunteers only. The approach may not translate to patients or improve real-world outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age greater than 18 and less than 65 years. 2. Able to understand and give informed consent/assent. 3. No prior neuropsychiatric, neurological disorders, epilepsy, or seizures. 4. No metal implants. 5. Absent of lesions or tumors from MRI scans. Exclusion Criteria: 1. The presence of a cardiac pacemaker or pacemaker wires. 2. Metallic particles in the eye. 3. Vascular clips in the head or previous neurosurgery. 4. Prosthetic heart valves. 5. Significant claustrophobia. 6. Non-fixed metallic particles (shrapnel). 7. Any magnetic metallic particles in the body. 8. Failure to assure non-pregnant status. 9. Failure to perform the task of lying still.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy volunteers only

Contacts and locations

Locations

  • MGH at the Navy Yard

    Charlestown, Massachusetts, 02129, United States

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