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Fiber fix? prebiotic shows promise for prediabetes in small study

NCT ID NCT02346838

Disease control Sponsor: Virginia Polytechnic Institute and State University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether taking a prebiotic fiber called inulin every day for 6 weeks could improve how the body handles sugar and fat in prediabetic adults. Twenty-two participants ate a controlled diet and either got inulin or a placebo. Researchers measured insulin sensitivity, metabolic flexibility, and heart health markers before and after the treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Inulin (a type of dietary fiber/prebiotic)
What this could lead to
If it works, this could point toward a simple dietary supplement to help manage prediabetes and reduce risk of type 2 diabetes.
What could go wrong
This is a very small, early-stage study with only 22 participants. Results may not apply to everyone, and the effect may be modest or not clinically significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

22 people

The number who actually took part.

Start date

Jan 2014

Finished

Jul 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women; postmenopausal women not taking hormone replacement therapy. * Fasting glucose between 5.6 - 6.9 mmol/L and/or a 2h plasma glucose between 7.8-11.1 mmol/L following a 75 g oral glucose tolerance test. * Weight stable for previous 6 months (+/- 2.0 kg). * Sedentary to recreationally active * Willing to be randomized to treatment or placebo. * Verbal and written informed consent. * No plans to gain/lose weight or change physical activity level. * Willing to pick up food daily, and consume foods provided for the 6-week controlled feeding period. Exclusion Criteria: * BMI less than 25 kg/m2 or greater than 40 kg/m2 or body mass greater than 300 pounds due to limit of DEXA. * Diabetes or diabetes medications * Prebiotic or probiotic supplement or product consumption in prior 3 months. * Total cholesterol \> 6.2 mmol/L; triglycerides \> 4.5 mmol/L. * Blood pressure \> 140/90 mmHg or antihypertensive medications. * Diagnosed inflammatory disease (e.g. lupus, irritable bowel, periodontal disease, etc) * Fructo, galacto-, xylo-oligosaccharide intake \> 3 g/day. * Past or current ischemic heart disease, stroke, respiratory disease, endocrine or metabolic disease, neurological disease, or hematological-oncological disease. * Smoking, alcohol consumption \> 2 servings /d for males and 1 serving/d for females, or taking medications (including but not limited to statins or other drugs with anti-inflammatory actions) or antioxidant vitamins or supplements. * Known allergy, hypersensitivity, or intolerance to inulin.

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Conditions

The condition(s) this trial relates to.

prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Prediabetes

Contacts and locations

Locations

  • Virginia Polytechnic and State University

    Blacksburg, Virginia, 24061, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.