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Freeze your pain away: new ACL surgery trick could slash opioid use

NCT ID NCT06603051

Symptom relief Sponsor: Virtua Health, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether freezing certain nerves in the knee before ACL reconstruction surgery can help control pain afterward and reduce the need for opioid painkillers. About 20 people having ACL surgery with their own tendon will be randomly assigned to get either standard care or standard care plus a nerve-freezing treatment (cryoneurolysis) a week before surgery. Researchers will track how much pain medication they use and how well their knee feels over 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cryoneurolysis (nerve freezing)
What this could lead to
If it works, this could offer a non-drug way to manage pain after ACL surgery, reducing reliance on opioids.
What could go wrong
This is a very small early trial (20 people) testing a procedure that may not reduce pain enough to make a real difference. It also carries risks like skin issues or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2024

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

14 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \- Patients aged 14 and over * Patients who are patients within the PI's practice * Patients who can speak and read English * Patients undergoing autograft ACL reconstruction. * Patients who are opioid naïve Exclusion Criteria: * \- Under the age of 14 * Non-English speaking/reading patients * Patients with Reynauds' syndrome * Patients with skin disorders or hypo-vascularity * Patients undergoing allograft ACL reconstruction. * Patients who consistently use opioids preoperatively

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acl repair

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Virtua Orthopedics Burlington

    RECRUITING

    Burlington, New Jersey, 08016, United States

  • Virtua Orthopedics Cherry Hill

    RECRUITING

    Cherry Hill, New Jersey, 08034, United States

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