Freeze your pain away: new ACL surgery trick could slash opioid use
NCT ID NCT06603051
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether freezing certain nerves in the knee before ACL reconstruction surgery can help control pain afterward and reduce the need for opioid painkillers. About 20 people having ACL surgery with their own tendon will be randomly assigned to get either standard care or standard care plus a nerve-freezing treatment (cryoneurolysis) a week before surgery. Researchers will track how much pain medication they use and how well their knee feels over 12 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
cryoneurolysis (nerve freezing)
What this could lead to
If it works, this could offer a non-drug way to manage pain after ACL surgery, reducing reliance on opioids.
What could go wrong
This is a very small early trial (20 people) testing a procedure that may not reduce pain enough to make a real difference. It also carries risks like skin issues or nerve damage.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Virtua Orthopedics Burlington
RECRUITINGBurlington, New Jersey, 08016, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Virtua Orthopedics Cherry Hill
RECRUITINGCherry Hill, New Jersey, 08034, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••