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Cure My Disease

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Could this antibody be the key to slowing Parkinson's?

NCT ID NCT07174310

Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 6 times

Summary

This study tests an experimental drug called prasinezumab in 900 people with early-stage Parkinson's disease who are already taking levodopa. The goal is to see if the drug can delay worsening of motor symptoms compared to a placebo. Participants receive the drug or placebo by IV infusion, and researchers track changes in movement over time.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 900 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Jun 2031

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Body weight within 40-110 kilograms (kg) (88-242 pounds \[lbs\]) and a body mass index within the range 18-34 kg/m2 * Diagnosis of idiopathic PD based on Movement Disorder Society (MDS) criteria * Has received monotherapy treatment * An MDS-UPDRS Part IV score of 0 at screening and prior to randomization * Hoehn and Yahr (H\&Y) Stage 1 or 2 off medication at screening and prior to randomization * Agreement to adhere to the contraception requirements Exclusion Criteria: * Pregnant or breastfeeding, or intention of becoming pregnant during the study or within the time frame in which contraception is required * Medical history indicating a parkinsonian syndrome other than idiopathic PD * Diagnosis of a significant neurologic disease other than PD * Chronic uncontrolled hypertension

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson's disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    190 sites in 17 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • A.O. Universitaria Pisana

    RECRUITING

    Pisa, Tuscany, 56126, Italy

  • AP-HM- Hôpital de La Timone

    RECRUITING

    Marseille, Bouches-du-Rhône, 13005, France

  • APHP - Hopital Henri Mondor

    RECRUITING

    Créteil, 94010, France

  • APHP - Hopital de la Pitie Salpetriere

    RECRUITING

    Paris, 75013, France

  • Aarhus Universitetshospital Skejby

    RECRUITING

    Aarhus N, 8200, Denmark

  • Advent Health Orlando

    RECRUITING

    Orlando, Florida, 32804, United States

  • Allegheny General Hospital

    RECRUITING

    Pittsburgh, Pennsylvania, 15212, United States

  • Asan Medical Center

    RECRUITING

    Seoul, 05505, South Korea

  • Asheville Neurology

    RECRUITING

    Asheville, North Carolina, 28806, United States

  • Avera Medical Group

    RECRUITING

    Sioux Falls, South Dakota, 57105, United States

  • Az. Osp. OO.RR. S. Giovanni di Dio e Ruggi D' Aragona

    RECRUITING

    Salerno, Campania, 84131, Italy

  • Azienda Ospedaliera Spedali Civili

    RECRUITING

    Brescia, Lombardy, 25100, Italy

  • Azienda Ospedaliera di Padova

    RECRUITING

    Padova, Veneto, 35128, Italy

  • Baptist Hospital of Miami

    RECRUITING

    Miami, Florida, 33176, United States

  • Barrow Neurological Institute

    RECRUITING

    Phoenix, Arizona, 85013, United States

  • Beijing Friendship Hospital Affiliated of Capital University of Medical Science

    RECRUITING

    Beijing, 100050, China

  • Beijing Hospital of Ministry of Health

    RECRUITING

    Beijing, 100730, China

  • Beijing Tian Tan Hospital,Capital Medical University

    RECRUITING

    Beijing, 100071, China

  • Bispebjerg Hospital;Neurologisk Afdeling

    RECRUITING

    København NV, 2400, Denmark

  • Boramae Medical Center

    RECRUITING

    Seoul, 07061, South Korea

  • CHU de Clermont-Ferrand - Site Gabriel-Montpied

    RECRUITING

    Clermont-Ferrand, 63000, France

  • CHU de Grenoble - Hôpital André Michallon

    RECRUITING

    La Tronche, 38700, France

  • CHU de Limoges - Hôpital Dupuytren

    RECRUITING

    Limoges, 87042, France

  • CHU de Montpellier - Hôpital Gui de Chauliac

    RECRUITING

    Montpellier, 34295, France

  • CHU de Nice Hopital Pasteur

    RECRUITING

    Nice, 06002, France

  • CHU de Toulouse - Hôpital Purpan

    RECRUITING

    Toulouse, 31059, France

  • CHUM

    RECRUITING

    Montreal, Quebec, H2X 0A9, Canada

  • CNS - Campus Neurológico

    RECRUITING

    Torres Vedras, 2560-280, Portugal

  • Campus for Ageing and Vitality

    RECRUITING

    Newcastle, NE4 5PL, United Kingdom

  • Central Texas Neurology Consultants

    RECRUITING

    Round Rock, Texas, 78681, United States

  • Centro Parkinson e Parkinsonismi

    RECRUITING

    Milan, Lombardy, 20126, Italy

  • Centro de Pesquisas Clinicas

    RECRUITING

    São Paulo, São Paulo, 01228-200, Brazil

  • Chang Gung Memorial Hospital - Linkou

    RECRUITING

    Taoyuan City, 333, Taiwan

  • Changhua Christian Hospital

    RECRUITING

    Changhua County, 500, Taiwan

  • Charing Cross Hospital

    RECRUITING

    London, W6 8RF, United Kingdom

  • Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin

    RECRUITING

    Berlin, 12203, Germany

  • Charite Universitätsmed. Berlin

    RECRUITING

    Berlin, 10117, Germany

  • Charter Research - Winter Park/Orlando

    RECRUITING

    Orlando, Florida, 32803, United States

  • China Medical University Hospital

    RECRUITING

    North Dist., 40447, Taiwan

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Cleveland Clinic Lou Ruvo

    RECRUITING

    Las Vegas, Nevada, 89106, United States

  • Columbia University Medical Center

    RECRUITING

    New York, New York, 10032, United States

  • Complejo Hospitalario Universitario A Coruña

    RECRUITING

    A Coruña, LA Coruna, 15006, Spain

  • Dent Neurological Institute

    RECRUITING

    Amherst, New York, 14226, United States

  • Duke University Medical Center

    RECRUITING

    Durham, North Carolina, 27705, United States

  • Faculdade de Medicina de Ribeirão Preto - Universidade de Sao Paulo

    RECRUITING

    Ribeirão Preto, São Paulo, 14051-140, Brazil

  • Faculdade de Medicina de Sao Jose do Rio Preto - FAMERP*X*

    RECRUITING

    São José do Rio Preto, São Paulo, 15090-000, Brazil

  • First Affiliated Hospital of Medical College of Xi'an Jiaotong University

    RECRUITING

    Xi'an, 710061, China

  • Fujian Medical University Union Hospital

    RECRUITING

    Fuzhou, 350001, China

  • Georgetown University

    RECRUITING

    Washington D.C., District of Columbia, 20007, United States

  • Grady Memorial Hospital

    RECRUITING

    Atlanta, Georgia, 30303, United States

  • Guangdong Provincial People's Hospital

    RECRUITING

    Guangzhou, 510115, China

  • Hackensack University Medical Center;Department of Neurology, Neuroscience Institute

    RECRUITING

    Paramus, New Jersey, 07652, United States

  • Hawaii Pacific Neuroscience

    RECRUITING

    Honolulu, Hawaii, 96817, United States

  • Heinrich-Heine Universitätsklinik Düsseldorf

    RECRUITING

    Düsseldorf, 40225, Germany

  • Hopital Roger Salengro

    RECRUITING

    Lille, 59037, France

  • Hospices Civils de Lyon - Hôpital Pierre Wertheimer

    RECRUITING

    Bron, Rhône, 69003, France

  • Hospital Clinic Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital Dr. Nélio Mendonça;Serviço de Neurologia

    RECRUITING

    Funchal, 9004-514, Portugal

  • Hospital General De Catalunya

    RECRUITING

    Sant Cugat del Vallès, Barcelona, 08195, Spain

  • Hospital General Universitario de Elche

    RECRUITING

    Elche, Alicante, 03203, Spain

  • Hospital General de Mexico

    RECRUITING

    Mexico City, Mexico CITY (federal District), 6726, Mexico

  • Hospital Pedro Hispano

    RECRUITING

    Matosinhos Municipality, 4464-513, Portugal

  • Hospital Quiron de Madrid

    RECRUITING

    Pozuelo de Alarcón, Madrid, 28223, Spain

  • Hospital Regional Universitario de Malaga ? Hospital General

    RECRUITING

    Málaga, 29009, Spain

  • Hospital Ruber Juan Bravo

    RECRUITING

    Madrid, 28006, Spain

  • Hospital Univ 12 de Octubre

    RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitari Vall d Hebron

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitario Fundación Alcorcón

    RECRUITING

    Alcorcón, Madrid, 28922, Spain

  • Hospital Universitario Virgen del Rocio

    RECRUITING

    Seville, 41013, Spain

  • Hospital Universitario de La Princesa

    RECRUITING

    Madrid, 28006, Spain

  • Hospital da Luz Coimbra

    RECRUITING

    Coimbra, 3020-479, Portugal

  • Hospital da Senhora da Oliveira-Guimarães

    RECRUITING

    Guimarães, Portugal

  • Hospital das Clinicas - UFMG

    RECRUITING

    Belo Horizonte, Minas Gerais, 31270-901, Brazil

  • Hospital de Braga

    RECRUITING

    Braga, 4710-243, Portugal

  • Hospital de Santa Maria

    RECRUITING

    Lisbon, 1649-035, Portugal

  • Huashan Hospital, Fudan University

    RECRUITING

    Shanghai, 200040, China

  • IRCCS Istituto Neurologico Carlo Besta

    RECRUITING

    Milan, Lombardy, 20133, Italy

  • IRCCS Ospedale San Raffaele

    RECRUITING

    Milan, Lombardy, 20132, Italy

  • IRCCS San Raffaele;Clinical Trial Center

    RECRUITING

    Rome, Lazio, 00166, Italy

  • Indywidualna Praktyka Lekarska Prof. Dr Hab. N. Med. Konrad Rejdak.

    RECRUITING

    Lublin, 20-410, Poland

  • Institute for Neurodegenerative Disorders

    RECRUITING

    New Haven, Connecticut, 06510, United States

  • Instituto Nacional de Neurologia y Neurocirugia

    RECRUITING

    Mexico City, Mexico CITY (federal District), 14390, Mexico

  • Instituto de Neurologia de Curitiba

    RECRUITING

    Curitiba, Paraná, 81210-310, Brazil

  • Instytut Zdrowia Dr Boczarska-Jedynak Sp. z o.o. Sp. k.

    RECRUITING

    Oświęcim, 32-600, Poland

  • Irccs A.O.U.San Martino Ist

    RECRUITING

    Genoa, Liguria, 16132, Italy

  • JEM Research LLC

    RECRUITING

    Atlantis, Florida, 33462, United States

  • K2 - Villages

    RECRUITING

    Lady Lake, Florida, 32159, United States

  • K2 Medical Research-Maitland

    RECRUITING

    Maitland, Florida, 32751, United States

  • Keck School of Medicine of USC

    RECRUITING

    Los Angeles, California, 900033, United States

  • Kepler Universitätsklinikum GmbH - Neuromed Campus

    RECRUITING

    Linz, 4020, Austria

  • Klinik Ottakring

    RECRUITING

    Vienna, 1160, Austria

  • Kliniken Beelitz GmbH

    RECRUITING

    Beelitz, 14547, Germany

  • Klinikum rechts der Isar der TU München

    RECRUITING

    Munich, 81675, Germany

  • Korea University Guro Hospital

    RECRUITING

    Seoul, 08308, South Korea

  • Krakowska Akademia Neurologii Sp z o.o. Centrum Neurologii K

    RECRUITING

    Krakow, 31-505, Poland

  • L2 Ip Instituto de Pesquisas Clinicas Ltda ME

    RECRUITING

    Brasília, Federal District, 70200-730, Brazil

  • LMU Klinikum, Neurologische Klinik und Poliklinik

    RECRUITING

    München, 81377, Germany

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

  • Mazowiecki Szpital Bródnowski w Warszawie Sp. z o.o.

    RECRUITING

    Warsaw, 03-242, Poland

  • Medizinische Hochschule Hannover, Klinik für Neurologie

    RECRUITING

    Hanover, 30625, Germany

  • Medizinische Universität Graz

    RECRUITING

    Graz, 8036, Austria

  • Medizinische Universität Wien

    WITHDRAWN

    Vienna, 1090, Austria

  • Monash Health

    RECRUITING

    Clayton, Victoria, 3168, Australia

  • Montreal Neurological Institute and Hospital

    RECRUITING

    Montreal, Quebec, H3A 2B4, Canada

  • NEURO-CARE Sp. z o.o. Sp. Komandytowa

    RECRUITING

    Katowice, 40-749, Poland

  • NZOZ Vitamed

    RECRUITING

    Bydgoszcz, 85-079, Poland

  • Nanjing Brain Hospital

    RECRUITING

    Nanjing, 210029, China

  • National Cheng Kung University Hospital

    RECRUITING

    Tainan, 704, Taiwan

  • National Taiwan University Hospital

    RECRUITING

    Taipei, 100, Taiwan

  • NeuroCare Center

    RECRUITING

    Canton, Ohio, 44718, United States

  • NeuroProtect

    RECRUITING

    Warsaw, 01-684, Poland

  • Neurology Center of North Orange County

    RECRUITING

    Fullerton, California, 92835, United States

  • Ninewells Hospital, Dundee- Scotland

    RECRUITING

    Dundee, DD2 1SY, United Kingdom

  • Nmedis sp. z o.o.

    RECRUITING

    Rzeszów, 35-232, Poland

  • Northwestern University Feinberg School Of Medicine

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Núcleo de Pesquisa do Rio Grande do Sul

    RECRUITING

    Porto Alegre, Rio Grande do Sul, 90430-001, Brazil

  • Oregon Health and Science University

    RECRUITING

    Portland, Oregon, 97239, United States

  • Ospedale Bellaria

    RECRUITING

    Bologna, Emilia-Romagna, 40139, Italy

  • Oxford University Hospitals NHS Foundation Trust

    RECRUITING

    Oxford, OX3 7LE, United Kingdom

  • Paracelsus Elena Klinik Kassel

    RECRUITING

    Kassel, 34128, Germany

  • Parkinson's Disease and Movement Disorders Center of Boca Raton

    RECRUITING

    Boca Raton, Florida, 33486, United States

  • Parkinson's Research Centers of America - Long Island

    RECRUITING

    Commack, New York, 11725, United States

  • Parkinson?s Research Centers of America ? Palo Alto

    RECRUITING

    Palo Alto, California, 94301, United States

  • Perron Institute for Neurological and Translational Science

    RECRUITING

    Nedlands, Western Australia, 6009, Australia

  • Plymouth Hospitals NHS Trust - Derriford Hospital

    RECRUITING

    Plymouth,Devon, PL6 8DH, United Kingdom

  • Podlaskie Centrum Psychogeriatrii

    WITHDRAWN

    Bia?ystok, 15-756, Poland

  • Policlinica Guipuzcoa

    RECRUITING

    Donostia / San Sebastian, Guipuzcoa, 20009, Spain

  • Policlinico Universitario Agostino Gemelli

    RECRUITING

    Rome, Lazio, 00168, Italy

  • Princess Alexandra Hospital

    RECRUITING

    Woolloongabba, Queensland, 4102, Australia

  • Profound Research LLC at The Neurology Center of Southern California

    RECRUITING

    Pasadena, California, 91105, United States

  • Quest Research Institute

    RECRUITING

    Farmington Hills, Michigan, 48334, United States

  • Regionshospitalet Gødstrup;Neurologisk Afdeling

    RECRUITING

    Herning, 7400, Denmark

  • Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

    RECRUITING

    Shanghai, 200127, China

  • Renown Health

    RECRUITING

    Reno, Nevada, 89502, United States

  • Rocky Mountain Movement Disorders

    RECRUITING

    Englewood, Colorado, 80113, United States

  • Royal Devon and Exeter Hospital (Wonford)

    RECRUITING

    Exeter, EX2 5DW, United Kingdom

  • Royal London Hospital

    RECRUITING

    London, E1 1FR, United Kingdom

  • Royal Melbourne Hospital

    RECRUITING

    Parkville, Victoria, 3050, Australia

  • Ruijin Hospital Shanghai Jiaotong University School of Medicine

    RECRUITING

    Shanghai, 200025, China

  • Samsung Medical Center

    RECRUITING

    Seoul, 06351, South Korea

  • San Raffaele Cassino

    RECRUITING

    Cassino, Lazio, 03043, Italy

  • Santa Casa de Misericordia de Salvador

    RECRUITING

    Salvador, Estado de Bahia, 40050-410, Brazil

  • Seoul National University Hospital

    RECRUITING

    Seoul, 110-744, South Korea

  • Severance Hospital, Yonsei University Health System

    RECRUITING

    Seoul, 03722, South Korea

  • Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University

    RECRUITING

    Hangzhou, China

  • Southern Neurology

    RECRUITING

    Kogarah, New South Wales, 2217, Australia

  • St. Josef-Hospital, Klinik für Neurologie

    RECRUITING

    Bochum, 44791, Germany

  • Stanford Neuroscience Health Center (SNHC)

    RECRUITING

    Stanford, California, 94304, United States

  • Szpital Sw. Wojciecha

    RECRUITING

    Gda?sk, 80-462, Poland

  • Taipei Veterans General Hospital

    RECRUITING

    Taipei, 11217, Taiwan

  • Texas Neurology PA

    RECRUITING

    Dallas, Texas, 75206, United States

  • The Affiliated Hospital of Xuzhou Medical University

    RECRUITING

    Xuzhou, China

  • The Alfred Hospital

    RECRUITING

    Prahan, Victoria, 3181, Australia

  • The First Affiliated Hospital of Guangzhou Medical University

    RECRUITING

    Guangzhou, 510120, China

  • The First Affiliated Hospital of Sun Yat-sen University

    RECRUITING

    Guangzhou, 510080, China

  • The First Affiliated Hospital, Chongqing Medical University

    RECRUITING

    Chongqing, 400016, China

  • The First Hospital of Jilin University

    RECRUITING

    Changchun, 130021, China

  • The Movement Disorder Clinic of Oklahoma

    RECRUITING

    Tulsa, Oklahoma, 74136, United States

  • The Second Affiliated Hospital of Soochow University

    RECRUITING

    Suzhou, 215004, China

  • The Second Affiliated Hospital of Zhejiang University School of Medicine

    RECRUITING

    Hangzhou, 310009, China

  • Tianjin Medical University General Hospital

    RECRUITING

    Tianjin, 300052, China

  • UC San Diego

    RECRUITING

    La Jolla, California, 92037, United States

  • UCLA Neurology Outpatient Clinic

    RECRUITING

    Los Angeles, California, 90095, United States

  • UCSF Weill Institute for Neurosciences

    RECRUITING

    San Francisco, California, 94158, United States

  • USF Parkinsons Disease and Movement Disorders Center

    RECRUITING

    Tampa, Florida, 33613, United States

  • Uniklinik fuer Neurologie, Medizinische Universitaet Innsbruck

    RECRUITING

    Innsbruck, 6020, Austria

  • Universitaettsklinikum Tübingen

    RECRUITING

    Tübingen, 72076, Germany

  • Universitatsklinikum Munster

    RECRUITING

    Münster, 48149, Germany

  • University Health Network

    RECRUITING

    Toronto, Ontario, M5G 2C4, Canada

  • University Pennsylvania Hospital

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

  • University of Alabama at Birmingham

    RECRUITING

    Birmingham, Alabama, 35233, United States

  • University of Kansas Medical Center

    RECRUITING

    Kansas City, Kansas, 66160, United States

  • University of New Mexico

    RECRUITING

    Albuquerque, New Mexico, 87106, United States

  • University of Vermont Medical Center

    RECRUITING

    Burlington, Vermont, 05401, United States

  • University of Virginia Health System

    RECRUITING

    Charlottesville, Virginia, 22903, United States

  • Università degli studi della Campania Luigi Vanvitelli

    RECRUITING

    Naples, Campania, 80138, Italy

  • Universität Des Saarlandes

    RECRUITING

    Homburg, 66421, Germany

  • Universitätsklinikum "Carl Gustav Carus"

    RECRUITING

    Dresden, 01307, Germany

  • Universitätsklinikum Erlangen, Abteilung Molekulare Neurologie

    RECRUITING

    Erlangen, 91054, Germany

  • Universitätsklinikum Freiburg, Klinik für Neurologie und Neurophysiologie

    RECRUITING

    Freiburg im Breisgau, 79106, Germany

  • Universitätsklinikum Heidelberg, Neurologische Klinik, Abteilung für Neuroradiologie

    RECRUITING

    Heidelberg, 69120, Germany

  • Universitätsklinikum Würzburg, Neurologische Klinik und Poliklinik

    RECRUITING

    Würzburg, 97080, Germany

  • VCU Health North Hospital

    RECRUITING

    Richmond, Virginia, 23298, United States

  • Vanderbilt University Medical Center

    RECRUITING

    Nashville, Tennessee, 37212, United States

  • Veracity Neuroscience

    RECRUITING

    Memphis, Tennessee, 38157, United States

  • Washington Uni School of Medicine

    RECRUITING

    St Louis, Missouri, 63110, United States

  • Weill Cornell Medical College

    RECRUITING

    New York, New York, 10021, United States

  • West China Hospital of Sichuan University

    RECRUITING

    Chengdu, 610041, China

  • West Virginia University

    RECRUITING

    Morgantown, West Virginia, 26506, United States

  • Westmead Hospital

    RECRUITING

    Westmead, New South Wales, 2145, Australia

  • Xuanwu Hospital, Capital Medical University

    RECRUITING

    Beijing, 100053, China

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