New stain could help surgeons spot hidden melanoma cells
NCT ID NCT07258446
First seen Jan 10, 2026 · Last updated Jun 23, 2026 · Updated 26 times
Summary
This study tests whether adding a special stain called PRAME to standard tissue analysis helps surgeons remove early-stage melanoma more accurately. About 36 adults with stage 0 to IIc melanoma will have slow Mohs surgery, and their tissue will be checked both with and without PRAME staining. The goal is to see if PRAME helps doctors decide when all cancer cells are gone, potentially reducing repeat surgeries or unnecessary removal of healthy skin.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PRAME immunohistochemistry staining
What this could lead to
If it works, this could make melanoma removal surgery more precise, reducing the chance of leaving cancer behind or removing too much healthy skin.
What could go wrong
This trial is small (36 people) and currently suspended. PRAME staining is still experimental, and it may not improve accuracy over standard methods.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.