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New stain could help surgeons spot hidden melanoma cells

NCT ID NCT07258446

Terminated Diagnosis Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a special stain called PRAME to standard tissue analysis helps surgeons remove early-stage melanoma more accurately. About 36 adults with stage 0 to IIc melanoma will have slow Mohs surgery, and their tissue will be checked both with and without PRAME staining. The goal is to see if PRAME helps doctors decide when all cancer cells are gone, potentially reducing repeat surgeries or unnecessary removal of healthy skin.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
PRAME immunohistochemistry staining
What this could lead to
If it works, this could make melanoma removal surgery more precise, reducing the chance of leaving cancer behind or removing too much healthy skin.
What could go wrong
This trial is small (36 people) and currently suspended. PRAME staining is still experimental, and it may not improve accuracy over standard methods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cutaneous melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLINICAL STAGE 0 CUTANEOUS MELANOMA AJCC V8 CLINICAL STAGE I CUTANEOUS MELANOMA AJCC V8 CLINICAL STAGE II CUTANEOUS MELANOMA AJCC V8

Contacts and locations

Locations

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

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