New hope for PNH patients failing standard therapy: experimental combo enters phase 3
NCT ID NCT07154745
First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 29 times
Summary
This study tests two experimental drugs, pozelimab and cemdisiran, in 35 adults with paroxysmal nocturnal hemoglobinuria (PNH) whose disease is still active despite standard C5 inhibitor therapy. The goal is to see if the combination can better control red blood cell destruction and improve lab markers. Participants will receive the drugs by injection and be monitored for safety and effectiveness over several months.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PAROXYSMAL NOCTURNAL HEMOGLOBINURIA are added.
Genom att skicka in godkänner du våra Användarvillkor
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
AOU Careggi
RECRUITINGFlorence, Tuscany, 50134, Italy
-
Ewha Womans University Mokdong Hospital
RECRUITINGSeoul, 07985, South Korea
-
Hospital General JM Morales Meseguer
RECRUITINGMurcia, 30008, Spain
-
Hospital San Pedro de Alcantara
RECRUITINGCáceres, 10003, Spain
-
Hospital Universitario Basurto
RECRUITINGBilbao, Vizcaya, 48013, Spain
-
Hospital Universitario de Salamanca
RECRUITINGSalamanca, 37007, Spain
-
In-Vivo Sp. z o.o.
RECRUITINGBydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-048, Poland
-
SC Hematology, AOU Città della Salute e della Scienza di Torino
RECRUITINGTorino, 10126, Italy
-
Samsung Medical Center
RECRUITINGSeoul, 6351, South Korea
-
Seoul National University Hospital
RECRUITINGSeoul, 03080, South Korea
-
Seoul St. Mary's Hospital - The Catholic University of Korea
RECRUITINGSeoul, 065791, South Korea
Conditions
Explore the condition pages connected to this study.