Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New pill aims to stop the itch of prurigo nodularis

NCT ID NCT06516965

Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests an oral drug called povorcitinib in 346 adults with prurigo nodularis, a condition causing intense itching and bumpy skin lesions. Participants receive either the drug or a placebo for 24 weeks. The study measures whether the drug reduces itch severity and clears skin lesions better than placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Povorcitinib (an oral tablet that targets inflammation)
What this could lead to
If it works, this could provide a new treatment option to control severe itching and skin bumps in prurigo nodularis.
What could go wrong
This is a phase 3 trial, but results are not yet available. The drug may not work better than placebo, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

346 people

The number who actually took part.

Started

Oct 2024

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male and female participants 18 to 75 years of age. * Clinical diagnosis of PN for at least 3 months prior to Screening visit. * Pruritus, defined as an average Itch NRS score ≥ 7 during the 7 days prior to Day 1/Baseline. * Total of ≥ 20 pruriginous lesions on ≥ 2 different body regions (both legs, and/or both arms, and/or trunk) at Screening and Day 1/Baseline. * Documented history of treatment failure, demonstrated intolerance, or contraindication to a previous PN treatment. * Willingness to avoid pregnancy or fathering children. Exclusion Criteria: * Chronic pruritus due to a condition other than PN or neuropathic and psychogenic pruritus. * Diagnosis of PN secondary to medications. * Active AD lesions (signs and symptoms other than dry skin) within 3 months prior to Screening visit. * Women who are pregnant (or are considering pregnancy) or breastfeeding. * Medical history including thrombocytopenia, coagulopathy or platelet dysfunction; venous and arterial thrombosis, deep vein thrombosis, pulmonary embolism, stroke, moderate to severe heart failure, cerebrovascular accident, myocardial infarction, or other significant cardiovascular diseases; Q-wave interval abnormalities; disseminated herpes zoster or dermatomal herpes zoster; disseminated herpes simplex; chronic/recurrent infections; malignancies. * Evidence of infection with TB, HBV, HCV or HIV. * History of failure to any topical or systemic JAK or TYK2 inhibitor as treatment of PN or any inflammatory disease. * Laboratory values outside of the protocol-defined ranges. Other protocol-defined Inclusion/Exclusion Criteria apply.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Prurigo nodularis are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

prurigo nodularis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Prurigo nodularis

Contacts and locations

Locations

  • Aesthetic General Dermatology of Seattle

    Burien, Washington, 98168, United States

  • Akk Medical Sp. Z O.O. - Centrum Medyczne Tu Sie Leczy

    Gdansk, 80-280, Poland

  • Allcutis Research, Llc

    Portsmouth, New Hampshire, 03801, United States

  • Alpha Research-Lucere Dermatology and Laser Clinic

    Edmonton, Alberta, T6X 0N9, Canada

  • Aoi Dermatology Clinic

    Kumamoto, 861-2236, Japan

  • Area Sanitaria de Santiago de Compostela Y Barbanza - Complejo Hospitalario Universitario de Santiag

    Santiago de Compostela, 15706, Spain

  • Az Sint-Jan Brugge Av

    Bruges, 08000, Belgium

  • Broadgreen Hospital - Liverpool University Hospitals Nhs Foundation Trust

    Liverpool, L14 3LB, United Kingdom

  • Care Clinic Sp. Z O.O.

    Katowice, 40-568, Poland

  • Center For Clinical and Cosmetic Research

    Aventura, Florida, 33180, United States

  • Central Japan International Medical Center

    Minokamo, 505-8510, Japan

  • Central Sooner Research

    Oklahoma City, Oklahoma, 73118, United States

  • Centre Hospitalier Universitaire (Chu) de Liege - Domaine Universitaire Du Sart Tilman

    Liège, 04000, Belgium

  • Centre de Recherche Saint-Louis

    Québec, Quebec, G1W 4R4, Canada

  • Centro Internacional de Estudios Clinicos

    Santiago, 8420383, Chile

  • Centro Medico Skinmed Limitada

    Santiago, 7580206, Chile

  • Cityclinic Przychodnia Lekarsko-Psychologiczna Matusiak Spolka Partnerska

    Wroclaw, 50566, Poland

  • Clinical Research Center Spolka Z Ograniczona Odpowiedzialnoscia Medic-R Spolka Komandytowa

    Poznan, 61-731, Poland

  • Clinical Research Chile Spa.

    Valdivia, 5090000, Chile

  • Clinical Science Institute Clinical Research Specialists Inc

    Santa Monica, California, 90404, United States

  • Clintrial S.R.O.

    Prague, 100 00, Czechia

  • Dermatologische Gemeinschaftspraxis Dres. Quist

    Mainz, 55128, Germany

  • Dermatology Associates Pc

    Rockville, Maryland, 20850, United States

  • Dermatology Specialists Research

    Louisville, Kentucky, 40241, United States

  • Dermeffects

    London, Ontario, N6H 5L5, Canada

  • Dermoklinika Centrum Medyczne S.C., M. Kierstan, J. Narbutt, A. Lesiak

    Lodz, 90-436, Poland

  • Direct Helpers Research Center

    Hialeah, Florida, 33012, United States

  • Dokkyo Medical University Saitama Medical Center

    Minamikoshigaya, 343-8555, Japan

  • Drk Krankenhaus Chemnitz-Rabenstein

    Chemnitz, 09117, Germany

  • Elbe Kliniken Buxtehude

    Buxtehude, 21614, Germany

  • First Oc Dermatology Research Inc

    Fountain Valley, California, 92708-3701, United States

  • Fivenson Dermatology

    Ann Arbor, Michigan, 48103, United States

  • Fremantle Dermatology

    Fremantle, 06160, Australia

  • Grand Hopital de Charleroi - Site Imtr

    Gilly, 06060, Belgium

  • Guy'S Hospital - Guy'S & St Thomas' Nhs Foundation Trust

    London, SE1 9RT, United Kingdom

  • Hautarztpraxis Dr. Hoffmann

    Witten, 58453, Germany

  • Henry Ford Health System

    Detroit, Michigan, 48202, United States

  • High-Med. Przychodnia Specjalistyczna

    Warsaw, 01-817, Poland

  • Hospital Clinico Universitario San Cecilio

    Granada, 18016, Spain

  • Hospital General Universitario Dr Balmis

    Alicante, 03010, Spain

  • Hospital Universitari Germans Trias I Pujol (Hugtp)

    Badalona, 08916, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario Puerta de Hierro de Majadahonda

    Majadahonda, 28222, Spain

  • Hospital Universitario Ramon Y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Reina Sofia

    Córdoba, 14004, Spain

  • Hospital Universitario Virgen Del Rocio

    Seville, 41013, Spain

  • Hospital de La Santa Creu I Sant Pau

    Barcelona, 08041, Spain

  • Hospital de Manises

    Manises, 46940, Spain

  • Investigate Md

    Scottsdale, Arizona, 85255, United States

  • Ipswich Hospital, East Suffolk and North Essex Nhs Foundation Trust

    Ipswich, IP4 5PD, United Kingdom

  • Klinikum Darmstadt

    Darmstadt, 64283, Germany

  • Klinikum Der Johann Wolfgang Goethe-Universitaet

    Frankfurt am Main, 60590, Germany

  • Klinikum Oldenburg Aor

    Oldenburg, 26133, Germany

  • Kume Derma Clinic

    Sakai, 593-8324, Japan

  • Luxderm Specjalistyczny Gabinet Dermatologiczny Prof. Dr. Hab. N. Med. Dorota Krasowska

    Lublin, 20-573, Poland

  • Magdeburger Company For Medical Studies and Services Gmbh

    Magdeburg, 39104, Germany

  • Medical Corporation Jun Dermatology Clinic

    Osaka, 558-0003, Japan

  • Medical Dermatology Specialists Phoenix

    Phoenix, Arizona, 85006, United States

  • Metro Boston Clinical Partners

    Brighton, Massachusetts, 02135-3511, United States

  • Michigan Dermatology Institute

    Waterford, Michigan, 48328, United States

  • Mics Centrum Medyczne Torun

    Torun, 87-100, Poland

  • Modern Research Associates Pllc

    Dallas, Texas, 75231, United States

  • National Defense Medical College Hospital

    Tokorozawa, 359-0042, Japan

  • Niigata University Medical & Dental Hospital

    Niigata, 951-8520, Japan

  • Nippon Medical School Musashikosugi Hospital

    Kawasaki-shi, 211-8533, Japan

  • Nodal Medical Center, Llc

    Tampa, Florida, 33607, United States

  • Noguchi Dermatology Clinic

    Kamimashiki-gun, 861-3101, Japan

  • Nomura Dermatology Clinic

    Yokohama, 221-0825, Japan

  • North York Research Inc.

    Toronto, Ontario, M2N 3A6, Canada

  • Novatrials

    Charlestown, New South Wales, 02290, Australia

  • OPTISKIN

    New York, New York, 10128, United States

  • Paddington Testing Co Inc

    Philadelphia, Pennsylvania, 19103, United States

  • Panstwowy Instytut Medyczny Mswia

    Warsaw, 02-507, Poland

  • Poole Hospital - University Hospitals Dorset Nhs Foundation Trust

    Poole, BH15 2JB, United Kingdom

  • Premier Specialists Pty Ltd

    Kogarah, New South Wales, 02217, Australia

  • Queen'S Square Medical Facilities

    Yokohama, 220-6208, Japan

  • Rosenpark Research Gmbh

    Darmstadt, 64283, Germany

  • Royalderm Agnieszka Nawrocka

    Warsaw, 02-692, Poland

  • Sanatorium Profesora Arenbergera

    Prague, 110 00, Czechia

  • Sanixtra Prague

    Prague, 158 00, Czechia

  • Santa Familia Ptg Lodz

    Lodz, 90-302, Poland

  • Sapporo Skin Clinic

    Sapporo, 600063, Japan

  • Schweiger Dermatology

    Boca Raton, Florida, 33428, United States

  • Schweiger Dermatology

    Hackensack, New Jersey, 07601, United States

  • Shimizu Dermatology Clinic

    Kobe, 657-0846, Japan

  • Simcoderm Medical and Surgical Dermatology Centre

    Barrie, Ontario, L4M 7G1, Canada

  • Skin & Cancer Foundation Australia

    Sydney, New South Wales, 02010, Australia

  • Skin Care Research, Llc

    Hollywood, Florida, 33201, United States

  • Skin Physicians

    Edmonton, Alberta, T6W 4V4, Canada

  • Skinsense Medical Research

    Saskatoon, Saskatchewan, S7K 2C1, Canada

  • Surrey and Sussex Healthcare Nhs Trust - East Surrey Hospital

    Redhill, United Kingdom

  • Tanpopo Dermatology Clinic

    Ōta-ku, 143-0023, Japan

  • Technischen Universitaet Muenchen

    München, 80802, Germany

  • The Alfred Hospital

    Melbourne, Victoria, 03004, Australia

  • The Dudley Group Nhs Foundation Trust

    Dudley, DY1 2HQ, United Kingdom

  • The Royal London Hospital - Barts Health Nhs Trust

    London, E1 1FR, United Kingdom

  • Tohoku University Hospital

    Sendai, 980-8574, Japan

  • Tokyo Medical University Hospital

    Shinjuku-ku, 160-0023, Japan

  • Tokyo Medical University Ibaraki Medical Center - Kasumigaura Campus (Tokyo Medical University Kasum

    Inashiki-gun, Japan

  • Tokyo Medical and Dental University Hospital, Faculty of Medicine

    Bunkyō City, 113-8519, Japan

  • Toronto Research Centre

    Toronto, Ontario, M3H 5Y8, Canada

  • Trueblue Clinical Research Moore Clinical Research, Inc McR Tampa Clinic Location

    Tampa, Florida, 33609, United States

  • Universitaetsmedizin Goettingen

    Göttingen, 37075, Germany

  • Universitair Ziekenhuis Gent (Uz Gent)

    Ghent, 09000, Belgium

  • Universitat de Valencia - Hospital Universitari I Politecnic La Fe de Valencia (Hospital La Fe Bulev

    Valencia, 46026, Spain

  • Universite Catholique de Louvain (Ucl) - Cliniques Universitaires Saint-Luc

    Woluwe-Saint-Lambert, 01200, Belgium

  • University Hospital Carl Gustav Carus

    Dresden, 01307, Germany

  • University Hospital Muenster

    Münster, 48149, Germany

  • University Hospital Rwth Aachen

    Aachen, 52074, Germany

  • University of Cincinnati Cancer Institute

    Cincinnati, Ohio, 45267, United States

  • University of Maryland School of Medicine

    Baltimore, Maryland, 21201, United States

  • University of Occupational and Environmental Health, Japan

    Kitakyushu, 807-8555, Japan

  • University of Utah Midvalley Dermatology

    Murray, Utah, 84107, United States

  • Uniwersytecki Szpital Kliniczny Im. Fryderyka Chopina W Rzeszowie

    Rzeszów, 35-055, Poland

  • Veracity Clinical Research Pty Ltd

    Woolloongabba, Queensland, 04102, Australia

  • Westmead Hospital

    Westmead, New South Wales, 02145, Australia

  • Yardley Dermatology Associates

    Yardley, Pennsylvania, 19067, United States

  • Ziaderm Research, Llc

    Miami, Florida, 33162, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.