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Zapping nerves to ease Post-Mastectomy pain: which target works best?

NCT ID NCT07675096

Symptom relief Sponsor: National Cancer Institute, Egypt Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests two types of pulsed radiofrequency—a procedure that uses electrical pulses to calm overactive nerves—for treating chronic pain after mastectomy. One targets the stellate ganglion in the neck, the other targets sympathetic ganglia in the upper back. Researchers will compare how well each reduces pain and improves daily function over six months in 75 women.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
pulsed radiofrequency
What this could lead to
If one method proves superior, it could offer a more effective, non-drug option for managing chronic pain after mastectomy.
What could go wrong
This is a small, early-stage comparison study. Results may not apply to all patients, and pain relief may vary or be temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 75 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female patients aged 18-60 years. * Patient of class II according to the American society of Anesthesiologists (ASA) physical status classification system. * History of unilateral mastectomy for breast cancer. * Persistent pain \>3 months postoperatively. * VAS score ≥4 despite pharmacological management. * Patients with neuropathic pain who has a score ≥4 by (DN4) questionnaire. * Patients on more than 1 antineuropathic drug. Exclusion Criteria: * Coagulopathy or anticoagulant therapy. * Local infection at injection site. * History of psychiatric illness or cognitive dysfunction. * Previous intervention in the same region (e.g., prior stellate ganglion block or thoracic radiofrequency ablation). * Allergy to local anesthetics or contrast agents.

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Conditions

The condition(s) this trial relates to.

Chronic Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic pain following surgical procedure for cancer Post-mastectomy pain syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Cancer Institute

    Cairo, Egypt

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