New model aims to forecast dementia risk in stroke survivors using genetics and brain imaging.
NCT ID NCT07660263
First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 2 times
Summary
This study collects a wide range of information from stroke survivors and healthy volunteers, including genetic data, brain scans, electrical brain activity, and thinking and memory tests. The goal is to build a model that can predict which stroke survivors are most likely to develop vascular dementia. The research does not test any treatment but aims to lay the groundwork for more personalized care after a stroke.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to a tool that helps doctors identify stroke survivors at high risk for dementia, enabling earlier monitoring and personalized care.
- What could go wrong
- This is an observational study, not a treatment trial. The prediction model may not be accurate enough for widespread use, and findings may not apply to all populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 300 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2026
- Expected to finish
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Dec 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Participants will be recruited from the Department of Rehabilitation Medicine at CHA Bundang Medical Center, Republic of Korea.
- Ages
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19 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Healthy Control Group: * Adults aged 19 years or older. * Able to be age- and sex-matched to the stroke cohort. * No history of stroke, transient ischemic attack (TIA), or other central nervous system disorders. * Cognitive function within the normal range for age and education level based on screening assessments (K-MMSE and K-MoCA). * Able to understand the study procedures and provide written informed consent. 2. Stroke Patient Group: * Adults aged 19 years or older. * First-ever ischemic or hemorrhagic stroke confirmed by CT or MRI. * Enrolled in one of the following strata according to time since stroke onset: Stratum A: 7 days to 3 months after stroke onset. Stratum B: \>3 months to 12 months after stroke onset. Stratum C: \>12 months to 36 months after stroke onset. \- Able to understand the study procedures and provide written informed consent, or consent provided by a legally authorized representative when applicable. Exclusion Criteria: 1. Healthy Control Group: * Current severe psychiatric disorders that may affect cognitive function (e.g., major depression, schizophrenia) or use of related medications. * Strong family history of hereditary cerebrovascular disorders (e.g., CADASIL). * Severe medical illness considered inappropriate for study participation. * Any condition that, in the opinion of the investigator, would make participation unsuitable. 2. Stroke Patient Group: * Impaired ability to provide consent (MMSE \<10) without an accompanying caregiver or legally authorized representative. * History of dementia due to causes other than stroke (e.g., Alzheimer's disease) prior to stroke onset. * History of major neurological disorders affecting cognition prior to stroke onset (e.g., Parkinson's disease, brain tumor, multiple sclerosis). * Severe aphasia or impaired consciousness preventing completion of cognitive assessments. * Current or pre-stroke severe psychiatric disorders that may affect cognitive function (e.g., major depression, schizophrenia) or use of related medications. * Strong family history of hereditary cerebrovascular disorders (e.g., CADASIL). * Contraindication to MRI (e.g., metallic implants) or refusal to provide blood samples for genomic analysis. * Any condition that, in the opinion of the investigator, would make participation unsuitable.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Bundang CHA Medical Center
RECRUITINGGyeonggi-do, Gyeonggi-do, 13497, South Korea
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